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    Asb8 ankyrin repeat and SOCS box-containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315287, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asb8provided by RGD
    Official Full Name
    ankyrin repeat and SOCS box-containing 8provided by RGD
    Primary source
    RGD:1309246
    See related
    EnsemblRapid:ENSRNOG00000075267 AllianceGenome:RGD:1309246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to be located in cytoplasm. Orthologous to human ASB8 (ankyrin repeat and SOCS box containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 349.3), Heart (RPKM 258.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asb8 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131140455..131176648, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129261397..129297492, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (139724337..139760410, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene phosphofructokinase, muscle Neighboring gene uncharacterized LOC134479569 Neighboring gene transfer RNA threonine (anticodon AGU) 34 Neighboring gene uncharacterized LOC120093732 Neighboring gene coiled-coil domain containing 184 Neighboring gene olfactory receptor family 10 subfamily AD member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 8
    Names
    ankyrin repeat and SOCS box-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108109.3 → NP_001101579.1  ankyrin repeat and SOCS box protein 8 isoform 1

      See identical proteins and their annotated locations for NP_001101579.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JWD3, B5DF17, F7F2V9
      Conserved Domains (3) summary
      PHA02876
      Location:26 → 215
      PHA02876; ankyrin repeat protein; Provisional
      cd03727
      Location:245 → 287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:56 → 83
      ANK; ANK repeat [structural motif]

    2. NM_001434706.1 → NP_001421635.1  ankyrin repeat and SOCS box protein 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JWD3, B5DF17, F7F2V9

    3. NM_001434707.1 → NP_001421636.1  ankyrin repeat and SOCS box protein 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JWD3, B5DF17, F7F2V9

    4. NM_001434708.1 → NP_001421637.1  ankyrin repeat and SOCS box protein 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JWD3, B5DF17, F7F2V9

    5. NM_001434709.1 → NP_001421638.1  ankyrin repeat and SOCS box protein 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007

    6. NM_001434710.1 → NP_001421639.1  ankyrin repeat and SOCS box protein 8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JWD3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      131140455..131176648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594889.3 → XP_017450378.3  ankyrin repeat and SOCS box protein 8 isoform X1

    2. XM_006242328.4 → XP_006242390.1  ankyrin repeat and SOCS box protein 8 isoform X2

      Related
      ENSRNOP00000102472.1, ENSRNOT00000139898.1
      Conserved Domains (3) summary
      PHA02876
      Location:26 → 215
      PHA02876; ankyrin repeat protein; Provisional
      cd03727
      Location:245 → 287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:56 → 83
      ANK; ANK repeat [structural motif]

    3. XM_006242329.4 → XP_006242391.1  ankyrin repeat and SOCS box protein 8 isoform X2

      Conserved Domains (3) summary
      PHA02876
      Location:26 → 215
      PHA02876; ankyrin repeat protein; Provisional
      cd03727
      Location:245 → 287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:56 → 83
      ANK; ANK repeat [structural motif]

    4. XM_017594890.3 → XP_017450379.1  ankyrin repeat and SOCS box protein 8 isoform X3

      Conserved Domains (3) summary
      cd03727
      Location:184 → 226
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:24 → 54
      ANK; ANK repeat [structural motif]
      cl39094
      Location:8 → 120
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_063263669.1 → XP_063119739.1  ankyrin repeat and SOCS box protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JWD3, B5DF17, F7F2V9
    Nucleotide Protein Strain
    Heading Accession and Version

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