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    Zwilch zwilch kinetochore protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691493, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zwilchprovided by RGD
    Official Full Name
    zwilch kinetochore proteinprovided by RGD
    Primary source
    RGD:1583880
    See related
    EnsemblRapid:ENSRNOG00000009303 AllianceGenome:RGD:1583880
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mitotic spindle assembly checkpoint signaling and protein localization to kinetochore. Predicted to be located in kinetochore. Predicted to be part of RZZ complex. Orthologous to human ZWILCH (zwilch kinetochore protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 71.0), Spleen (RPKM 65.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zwilch in Genome Data Viewer
    Location:
    8q24
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (73532968..73566214, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (64638401..64670911, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (69089449..69121420, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene SMAD family member 3 Neighboring gene SMAD family member 6 Neighboring gene U12 minor spliceosomal RNA Neighboring gene small nucleolar RNA SNORD18 Neighboring gene lactase-like Neighboring gene small nucleolar RNA, C/D box 16 Neighboring gene ribosomal protein L4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. Civril F, et al. Structure, 2010 May 12. PMID 20462495
    2. Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. Williams BC, et al. Mol Biol Cell, 2003 Apr. PMID 12686595, Free PMC Article
    3. ZW10 links mitotic checkpoint signaling to the structural kinetochore. Kops GJ, et al. J Cell Biol, 2005 Apr 11. PMID 15824131, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RZZ complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RZZ complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein zwilch homolog
    Names
    Zwilch, kinetochore associated, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427745.1 → NP_001414674.1  protein zwilch homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AIC8
      Related
      ENSRNOP00000093863.2, ENSRNOT00000096655.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      73532968..73566214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266191.1 → XP_063122261.1  protein zwilch homolog isoform X1

      UniProtKB/TrEMBL
      A6J5B4

    2. XM_039082443.2 → XP_038938371.1  protein zwilch homolog isoform X1

      UniProtKB/TrEMBL
      A6J5B4
      Conserved Domains (1) summary
      pfam09817
      Location:1 → 457
      Zwilch; RZZ complex, subunit zwilch

    3. XM_063266190.1 → XP_063122260.1  protein zwilch homolog isoform X1

      UniProtKB/TrEMBL
      A6J5B4

    4. XM_063266192.1 → XP_063122262.1  protein zwilch homolog isoform X1

      UniProtKB/TrEMBL
      A6J5B4

    5. XM_039082445.2 → XP_038938373.1  protein zwilch homolog isoform X2

      Conserved Domains (1) summary
      pfam09817
      Location:16 → 337
      Zwilch; RZZ complex, subunit zwilch

    RNA

    1. XR_010054029.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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