Arc activity-regulated cytoskeleton-associated protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arcprovided by RGD
Official Full Name: activity-regulated cytoskeleton-associated proteinprovided by RGD
Primary source: RGD:62037
See related: EnsemblRapid:ENSRNOG00000043465 AllianceGenome:RGD:62037
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rg3.1
Summary: Enables mRNA binding activity. Involved in several processes, including learning or memory; positive regulation of AMPA receptor activity; and regulation of synaptic plasticity. Located in actin cytoskeleton and extracellular vesicle. Is active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic endosome. Used to study anxiety disorder and morphine dependence. Biomarker of anxiety disorder; middle cerebral artery infarction; visual epilepsy; and withdrawal disorder. Orthologous to human ARC (activity regulated cytoskeleton associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 60.4), Thymus (RPKM 24.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (108444959..108448413, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (106555968..106559697, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (115907097..115911059, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced expression of activity-regulated cytoskeleton-associated protein in the medial prefrontal cortex is involved in working memory performance.
Title: Enhanced expression of activity-regulated cytoskeleton-associated protein in the medial prefrontal cortex is involved in working memory performance.
Arc regulates brain damage and neuroinflammation via Sirt1 signaling following subarachnoid hemorrhage.
Title: Arc regulates brain damage and neuroinflammation via Sirt1 signaling following subarachnoid hemorrhage.
Post-training intra-basolateral complex of the amygdala infusions of clenbuterol enhance memory for conditioned place preference and increase ARC protein expression in dorsal hippocampal synaptic fractions.
Title: Post-training intra-basolateral complex of the amygdala infusions of clenbuterol enhance memory for conditioned place preference and increase ARC protein expression in dorsal hippocampal synaptic fractions.
Changes in concentrations of NMDA receptor subunit GluN2B, Arc and syntaxin-1 in dorsal hippocampus Schaffer collateral synapses in a rat learned helplessness model of depression.
Title: Changes in concentrations of NMDA receptor subunit GluN2B, Arc and syntaxin-1 in dorsal hippocampus Schaffer collateral synapses in a rat learned helplessness model of depression.
Experience-dependent persistent Arc expression is reduced in the aged hippocampus.
Title: Experience-dependent persistent Arc expression is reduced in the aged hippocampus.
Survey of the Arc Epigenetic Landscape in Normal Cognitive Aging.
Title: Survey of the Arc Epigenetic Landscape in Normal Cognitive Aging.
Arc silence aggravates traumatic neuronal injury via mGluR1-mediated ER stress and necroptosis.
Title: Arc silence aggravates traumatic neuronal injury via mGluR1-mediated ER stress and necroptosis.
Study shows that ICV PACAP given prior to fear conditioning results in significant elevations in Arc levels in the central nucleus of the amygdala and bed nucleus of the stria terminalis but not the dorsal hippocampus or LA/BLA complex.
Title: PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats.
these findings suggest a novel mechanism by which MKL2 controls the Arc synaptic activity-responsive element in response to BDNF stimulation
Title: Involvement of SRF coactivator MKL2 in BDNF-mediated activation of the synaptic activity-responsive element in the Arc gene.
MEF2A knockdown prevents metabotropic glutamate receptor (mGluR)-dependent GluA2 internalisation without compromising Arc protein induction, suggesting that this pathway does not involve Arc.
Title: MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1.

Submit: New GeneRIF Correction See all GeneRIFs (125)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C86064 (e-PCR)
- UniSTS:165936

RH137921 (e-PCR)
- UniSTS:220008

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endoderm development	ISO Inferred from Sequence Orthology more info
involved_in learning	IEP Inferred from Expression Pattern more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA transport	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of AMPA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dendritic spine morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term synaptic depression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuronal synaptic plasticity	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to morphine	IEP Inferred from Expression Pattern more info	PubMed
involved_in vesicle-mediated intercellular transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic endosome	IMP Inferred from Mutant Phenotype more info	PubMed
located_in virus-like capsid	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: activity-regulated cytoskeleton-associated protein

Names: ARC/ARG3.1; activity regulated cytoskeletal-associated protein; activity-regulated gene 3.1 protein; arg3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019361.2 → NP_062234.2 activity-regulated cytoskeleton-associated protein

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q62743, Q63053

UniProtKB/TrEMBL

A6HRX2

Related

ENSRNOP00000101948.1, ENSRNOT00000145814.1

Conserved Domains (1) summary

pfam18162
Location:278 → 360

Arc_C; Arc C-lobe

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

108444959..108448413 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595064.3 → XP_017450553.1 activity-regulated cytoskeleton-associated protein isoform X1

UniProtKB/Swiss-Prot

Q62743, Q63053

UniProtKB/TrEMBL

A6HRX2

Conserved Domains (1) summary

pfam18162
Location:278 → 360

Arc_C; Arc C-lobe