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    Calb2 calbindin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117059, updated on 9-Dec-2024

    Summary

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    Symbol
    Calb2provided by RGD
    Full Name
    calbindin 2provided by RGD
    Primary source
    RGD:620981
    See related
    AllianceGenome:RGD:620981
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium ion binding activity. Predicted to be involved in regulation of long-term synaptic potentiation and regulation of presynaptic cytosolic calcium ion concentration. Located in cuticular plate and stereocilium. Is active in synapse. Orthologous to human CALB2 (calbindin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 382.5) and Testes (RPKM 140.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Calb2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55023849..55050858, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38114435..38141438, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (41482743..41509617)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene TLE family member 7 Neighboring gene uncharacterized LOC102553877 Neighboring gene 40S ribosomal protein S18 pseudogene Neighboring gene uncharacterized LOC134483364

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla. Szalak R, et al. Pol J Vet Sci, 2015. PMID 26812830
    2. Neonatal hypoxic/ischemic brain injury induces production of calretinin-expressing interneurons in the striatum. Yang Z, et al. J Comp Neurol, 2008 Nov 1. PMID 18720478, Free PMC Article
    3. Calretinin gene promoter activity is differently regulated in neurons and cancer cells. Role of AP2-like cis element and zinc ions. Billing-Marczak K, et al. Biochim Biophys Acta, 2004 Apr 16. PMID 15093134
    4. Neurogenesis and stereological morphometry of calretinin-immunoreactive GABAergic interneurons of the neostriatum. Rymar VV, et al. J Comp Neurol, 2004 Feb 9. PMID 14730585
    5. The Ca(2+)-binding protein calretinin is selectively enriched in a subpopulation of the epithelial rests of Malassez. Korkmaz Y, et al. Cell Tissue Res, 2010 Dec. PMID 21080000

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of calbindin and calretinin in the dorsomedial and ventromedial hypothalamic nuclei during aging.
      Title: Expression of calbindin and calretinin in the dorsomedial and ventromedial hypothalamic nuclei during aging.
    2. Quantitative analysis of the transient changes in calretinin expression by hybridochemistry within neuronal cell populations in the hippocampus of a beta amyloid-treated rat model of Alzheimer's disease and their correlation with endocannabinoid increase
      Title: Analysis of calretinin early expression in the rat hippocampus after beta amyloid (1-42) peptide injection.
    3. A role for calreticulin in functioning of mitochondrial ATP-dependent potassium channel
      Title: [A role for calreticulin in functioning of mitochondrial ATP-dependent potassium channel].
    4. distribution of the cell-specific markers, calretinin and calbindin, in reelin-immunoreactive cells during postnatal rat and mouse neocortical development
      Title: Expression of calcium-binding proteins in layer 1 reelin-immunoreactive cells during rat and mouse neocortical development.
    5. The stress of maternal deprivation has a significant effect on calretinin and calbindin expression in both male and female ratss, but affects glucocorticoid receptor levels only in males.
      Title: The effect of different maternal deprivation paradigms on the expression of hippocampal glucocorticoid receptors, calretinin and calbindin-D28k in male and female adolescent rats.
    6. An essential property of calretinin action potentials is a delayed equilibration with divalent calcium ions.
      Title: Effects of calretinin on Ca2+ signals in cerebellar granule cells: implications of cooperative Ca2+ binding.
    7. Studied the general pattern of calretinin (CR), parvalbumin (PV) and calbindin (CB) immunoreactivity as well as morphological features and density of CR and PV immunoreactive (CR+, PV+) interneurons in the rat perirhinal cortex (PRC) and found the PRC possesses specific interneuronal equipment with unusually high proportion of CR+ interneurons.
      Title: Calretinin, parvalbumin and calbindin immunoreactive interneurons in perirhinal cortex and temporal area Te3V of the rat brain: qualitative and quantitative analyses.
    8. results suggest that hypothyroidism ameliorated the diabetes-induced reduction of CB, CR, and PV immunoreactivity in the hippocampus
      Title: Hypothyroid states mitigate the diabetes-induced reduction of calbindin D-28k, calretinin, and parvalbumin immunoreactivity in type 2 diabetic rats.
    9. study concludes that, in inner and outer enamel epithelial cells, Ca(2+)is regulated by calbindin, parvalbumin and calretinin during tooth development; in epithelial rests of Malassez of adult periodontal ligament, Ca(2+) is regulated only by calretinin
      Title: The Ca(2+)-binding protein calretinin is selectively enriched in a subpopulation of the epithelial rests of Malassez.
    10. There is a clear compartmentalization of calbindin-28 kDa and calretinin distribution in retinal ganglion cells.
      Title: Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105356

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of long-term synaptic potentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of presynaptic cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cuticular plate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in gap junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in parallel fiber to Purkinje cell synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stereocilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in terminal bouton HDA PubMed 
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vestibular calyx terminal ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calretinin
    Names
    CR

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053988.2 → NP_446440.1  calretinin

      See identical proteins and their annotated locations for NP_446440.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      P47728
      UniProtKB/TrEMBL
      A0A8I6ADK6, A6IZ54
      Conserved Domains (1) summary
      cd16177
      Location:21 → 268
      EFh_HEF_CR; EF-hand, calcium binding motif, found in calretinin (CR)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      55023849..55050858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47728.1 GenPept UniProtKB/Swiss-Prot:P47728

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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