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    Trmt1 tRNA methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trmt1provided by RGD
    Official Full Name
    tRNA methyltransferase 1provided by RGD
    Primary source
    RGD:1305992
    See related
    EnsemblRapid:ENSRNOG00000002914 AllianceGenome:RGD:1305992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305992
    Summary
    Predicted to enable tRNA (guanine(26)-N2)-dimethyltransferase activity. Predicted to be involved in tRNA N2-guanine methylation. Predicted to be located in mitochondrion. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 68. Orthologous to human TRMT1 (tRNA methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 65.3), Thymus (RPKM 50.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trmt1 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40361583..40374971, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23456756..23471581, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25798262..25813458)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene nuclear factor I X Neighboring gene uncharacterized LOC120098485 Neighboring gene LYL1, basic helix-loop-helix family member Neighboring gene nucleus accumbens associated 1 Neighboring gene immediate early response 2 Neighboring gene calcium voltage-gated channel subunit alpha1 A Neighboring gene uncharacterized LOC134483326

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The human tRNA(m(2)(2)G(26))dimethyltransferase: functional expression and characterization of a cloned hTRM1 gene. Liu J, et al. Nucleic Acids Res, 2000 Sep 15. PMID 10982862, Free PMC Article
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(26)-N2)-dimethyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA N2-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanine(26)-N(2))-dimethyltransferase
    Names
    N(2),N(2)-dimethylguanosine tRNA methyltransferase
    TRM1 tRNA methyltransferase 1 homolog
    tRNA methyltransferase 1 homolog
    NP_001013892.2
    XP_006255298.1
    XP_008770587.1
    XP_008770588.1
    XP_063133900.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013870.2 → NP_001013892.2  tRNA (guanine(26)-N(2))-dimethyltransferase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5ZNF7
      Related
      ENSRNOP00000003941.6, ENSRNOT00000003941.8
      Conserved Domains (2) summary
      smart00356
      Location:599 → 625
      ZnF_C3H1; zinc finger
      pfam02005
      Location:61 → 499
      TRM; N2,N2-dimethylguanosine tRNA methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40361583..40374971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255236.4 → XP_006255298.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006255298.1

      UniProtKB/TrEMBL
      A0A140UHW6, A0A8I6A6S2
      Related
      ENSRNOP00000101752.1, ENSRNOT00000130211.1
      Conserved Domains (2) summary
      smart00356
      Location:574 → 600
      ZnF_C3H1; zinc finger
      pfam02005
      Location:36 → 474
      TRM; N2,N2-dimethylguanosine tRNA methyltransferase

    2. XM_008772365.4 → XP_008770587.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNF7
      Conserved Domains (2) summary
      smart00356
      Location:599 → 625
      ZnF_C3H1; zinc finger
      pfam02005
      Location:61 → 499
      TRM; N2,N2-dimethylguanosine tRNA methyltransferase

    3. XM_008772366.4 → XP_008770588.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X2

      See identical proteins and their annotated locations for XP_008770588.1

      UniProtKB/TrEMBL
      A0A140UHW6, A0A8I6A6S2
      Conserved Domains (2) summary
      smart00356
      Location:574 → 600
      ZnF_C3H1; zinc finger
      pfam02005
      Location:36 → 474
      TRM; N2,N2-dimethylguanosine tRNA methyltransferase

    4. XM_063277830.1 → XP_063133900.1  tRNA (guanine(26)-N(2))-dimethyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A140UHW6, A0A8I6A6S2
    Nucleotide Protein Strain
    Heading Accession and Version

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