Cetn1 centrin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cetn1provided by RGD
Official Full Name: centrin 1provided by RGD
Primary source: RGD:620246
See related: EnsemblRapid:ENSRNOG00000084288 AllianceGenome:RGD:620246
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; calcium ion binding activity; and heterotrimeric G-protein binding activity. Predicted to be involved in centriole replication. Predicted to act upstream of or within cellular response to heat. Predicted to be located in microtubule organizing center; photoreceptor connecting cilium; and spindle pole. Predicted to be active in centriole; centrosome; and nucleus. Orthologous to human CETN1 (centrin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 18p13

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (924428..925130, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (651591..652293, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (785972..786674, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cen1 and Cen2 contribute to the centrin-transducin complex and potentially participate in the regulation of transducin translocation through the photoreceptor cilium
Title: Differential expression and interaction with the visual G-protein transducin of centrin isoforms in mammalian photoreceptor cells.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein beta/gamma-subunit complex binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables heterotrimeric G-protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in centriole replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor connecting cilium	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centrin-1

Names: EF-hand protein; centrin, EF-hand protein, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.