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    Large2 LARGE xylosyl- and glucuronyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311202, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Large2provided by RGD
    Official Full Name
    LARGE xylosyl- and glucuronyltransferase 2provided by RGD
    Primary source
    RGD:735214
    See related
    EnsemblRapid:ENSRNOG00000006353 AllianceGenome:RGD:735214
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gyltl1b
    Summary
    Predicted to enable dystroglycan binding activity; glucuronosyltransferase activity; and xylosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in Golgi apparatus. Orthologous to human LARGE2 (LARGE xylosyl- and glucuronyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 39.1), Lung (RPKM 17.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Large2 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (98791543..98800251, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (78334627..78347167, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (81276020..81285457, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene PHD finger protein 21A Neighboring gene large ribosomal subunit protein eL34-like Neighboring gene small nucleolar RNA SNORA21 Neighboring gene uncharacterized LOC134486123 Neighboring gene peroxisomal biogenesis factor 16 Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 Neighboring gene Frey regulator of sperm-oocyte fusion 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE. Ashikov A, et al. Glycobiology, 2013 Mar. PMID 23135544
    2. Xylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2. Inamori K, et al. Glycobiology, 2013 Mar. PMID 23125099, Free PMC Article
    3. Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of α-dystroglycan in cells and tissues. Inamori K, et al. J Biol Chem, 2014 Oct 10. PMID 25138275, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72631

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dystroglycan binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xylosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables xylosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables xylosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked mannosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein O-linked mannosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked mannosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    xylosyl- and glucuronyltransferase LARGE2
    Names
    glycosyltransferase-like 1B
    glycosyltransferase-like protein LARGE2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199107.2 → NP_954538.1  xylosyl- and glucuronyltransferase LARGE2

      See identical proteins and their annotated locations for NP_954538.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6P7A1
      UniProtKB/TrEMBL
      A6HNG2, A6HNG3
      Conserved Domains (2) summary
      cd06431
      Location:67 → 346
      GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
      pfam13896
      Location:401 → 635
      Glyco_transf_49; Glycosyl-transferase for dystroglycan

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      98791543..98800251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283669.1 → XP_063139739.1  xylosyl- and glucuronyltransferase LARGE2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QLT7, A6HNG3

    2. XM_006234562.5 → XP_006234624.1  xylosyl- and glucuronyltransferase LARGE2 isoform X1

      See identical proteins and their annotated locations for XP_006234624.1

      UniProtKB/TrEMBL
      A6HNG3
      Conserved Domains (3) summary
      cd06431
      Location:92 → 371
      GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
      COG1442
      Location:93 → 340
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
      pfam13896
      Location:426 → 660
      Glyco_transf_49; Glycosyl-transferase for dystroglycan

    3. XM_017591719.3 → XP_017447208.1  xylosyl- and glucuronyltransferase LARGE2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ACM6, A6HNG3
      Related
      ENSRNOP00000089432.1, ENSRNOT00000098647.2

    4. XM_063283670.1 → XP_063139740.1  xylosyl- and glucuronyltransferase LARGE2 isoform X4

      UniProtKB/TrEMBL
      A6HNG3

    5. XM_063283671.1 → XP_063139741.1  xylosyl- and glucuronyltransferase LARGE2 isoform X7

      UniProtKB/TrEMBL
      A6HNG3

    6. XM_017591718.3 → XP_017447207.1  xylosyl- and glucuronyltransferase LARGE2 isoform X5

      UniProtKB/TrEMBL
      A6HNG3

    7. XM_006234566.5 → XP_006234628.1  xylosyl- and glucuronyltransferase LARGE2 isoform X3

      UniProtKB/TrEMBL
      A6HNG3
      Conserved Domains (3) summary
      cd06431
      Location:68 → 347
      GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
      COG1442
      Location:69 → 316
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
      pfam13896
      Location:402 → 606
      Glyco_transf_49; Glycosyl-transferase for dystroglycan

    8. XM_006234564.5 → XP_006234626.1  xylosyl- and glucuronyltransferase LARGE2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QLT7, A6HNG3
      Related
      ENSRNOP00000041797.3, ENSRNOT00000051258.5
      Conserved Domains (3) summary
      cd06431
      Location:68 → 347
      GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
      COG1442
      Location:69 → 316
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
      pfam13896
      Location:402 → 636
      Glyco_transf_49; Glycosyl-transferase for dystroglycan

    9. XM_008762024.4 → XP_008760246.1  xylosyl- and glucuronyltransferase LARGE2 isoform X1

      See identical proteins and their annotated locations for XP_008760246.1

      UniProtKB/TrEMBL
      A6HNG3
      Related
      ENSRNOP00000100953.1, ENSRNOT00000147683.1
      Conserved Domains (3) summary
      cd06431
      Location:92 → 371
      GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
      COG1442
      Location:93 → 340
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
      pfam13896
      Location:426 → 660
      Glyco_transf_49; Glycosyl-transferase for dystroglycan
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P7A1.1 GenPept UniProtKB/Swiss-Prot:Q6P7A1

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