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    Pals2 protein associated with LIN7 2, MAGUK p55 family member [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362359, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pals2provided by RGD
    Official Full Name
    protein associated with LIN7 2, MAGUK p55 family memberprovided by RGD
    Primary source
    RGD:1311833
    See related
    EnsemblRapid:ENSRNOG00000021579 AllianceGenome:RGD:1311833
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mpp6
    Summary
    Predicted to be active in cell-cell junction and plasma membrane. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 115.9), Brain (RPKM 100.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pals2 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (80504298..80584951)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (79173488..79257542)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (79846506..79928977)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene neuropeptide Y Neighboring gene uncharacterized LOC102555694 Neighboring gene basic proline-rich protein-like Neighboring gene gasdermin E Neighboring gene oxysterol binding protein-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of Pals, proteins associated with mLin-7. Kamberov E, et al. J Biol Chem, 2000 Apr 14. PMID 10753959
    2. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, et al. J Biol Chem, 2004 May 21. PMID 15024025
    3. An overview of pre-ribosomal RNA processing in eukaryotes. Henras AK, et al. Wiley Interdiscip Rev RNA, 2015 Mar-Apr. PMID 25346433, Free PMC Article
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189400

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein PALS2
    Names
    CH474011:EDL88200
    MAGUK p55 subfamily member 6
    membrane palmitoylated protein 6
    membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
    protein associated with LIN7 2, MAGUK family member

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134982.1 → NP_001128454.1  protein PALS2

      See identical proteins and their annotated locations for NP_001128454.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169025
      UniProtKB/TrEMBL
      A0A0G2K4N7, A0A9K3Y6Q0, B5DFE0, D3ZW03
      Related
      ENSRNOP00000037380.6, ENSRNOT00000029332.8
      Conserved Domains (6) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:219 → 279
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      smart00072
      Location:347 → 528
      GuKc; Guanylate kinase homologues
      cd00992
      Location:133 → 206
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:337 → 527
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      80504298..80584951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107787.2 → XP_038963715.1  protein PALS2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4N7, A0A8I6GMH8, A6K0L7
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:233 → 293
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:133 → 206
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:351 → 541
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    2. XM_006236496.5 → XP_006236558.1  protein PALS2 isoform X2

      See identical proteins and their annotated locations for XP_006236558.1

      UniProtKB/TrEMBL
      A0A0G2K4N7, A0A8I6GMH8, A6K0L7
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:233 → 293
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:133 → 206
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:351 → 541
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    3. XM_039107784.2 → XP_038963712.1  protein PALS2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4N7, A0A8I6GMH8, A6K0L7
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:233 → 293
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:133 → 206
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:351 → 541
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    4. XM_006236497.5 → XP_006236559.1  protein PALS2 isoform X2

      See identical proteins and their annotated locations for XP_006236559.1

      UniProtKB/TrEMBL
      A0A0G2K4N7, A0A8I6GMH8, A6K0L7
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:233 → 293
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:133 → 206
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:351 → 541
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    5. XM_039107785.2 → XP_038963713.1  protein PALS2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4N7, A0A8I6GMH8, A6K0L7
      Related
      ENSRNOP00000073113.3, ENSRNOT00000089973.3
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:233 → 293
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:133 → 206
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:351 → 541
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    6. XM_039107786.2 → XP_038963714.1  protein PALS2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4N7, A0A8I6GMH8, A6K0L7
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:233 → 293
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:133 → 206
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:351 → 541
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    7. XM_008762897.4 → XP_008761119.1  protein PALS2 isoform X2

      See identical proteins and their annotated locations for XP_008761119.1

      UniProtKB/TrEMBL
      A0A0G2K4N7, A0A8I6GMH8, A6K0L7
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:233 → 293
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:133 → 206
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:351 → 541
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    8. XM_063286255.1 → XP_063142325.1  protein PALS2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4N7
      Related
      ENSRNOP00000097400.2, ENSRNOT00000096577.2

    9. XM_063286256.1 → XP_063142326.1  protein PALS2 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K4N7

    10. XM_063286254.1 → XP_063142324.1  protein PALS2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4N7

    11. XM_039107788.2 → XP_038963716.2  protein PALS2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K4N7

    RNA

    1. XR_005503249.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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