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    Cirbp cold inducible RNA binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81825, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cirbpprovided by RGD
    Official Full Name
    cold inducible RNA binding proteinprovided by RGD
    Primary source
    RGD:620756
    See related
    EnsemblRapid:ENSRNOG00000088478 AllianceGenome:RGD:620756
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity and translation repressor activity. Predicted to be involved in positive regulation of gene expression; response to UV; and stress granule assembly. Predicted to act upstream of or within cellular response to cold; negative regulation of cell growth; and regulation of cell cycle G1/S phase transition. Predicted to be located in cytoplasmic stress granule and nucleoplasm. Predicted to be part of spliceosomal complex. Orthologous to human CIRBP (cold inducible RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 236.7), Adrenal (RPKM 202.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cirbp in Genome Data Viewer
    Location:
    7q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10184515..10189623, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9533857..9538899, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12400066..12405054, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ephrin A2 Neighboring gene family with sequence similarity 174 member C Neighboring gene midnolin Neighboring gene ATP synthase F1 subunit delta Neighboring gene CACN subunit beta associated regulatory protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Upregulation of CIRP by its agonist prevents the development of heart failure in myocardial infarction rats. Zhang J, et al. BMC Cardiovasc Disord, 2024 Mar 27. PMID 38539067, Free PMC Article
    2. Deficiency of cold-inducible RNA-binding protein exacerbated monocrotaline-induced pulmonary artery hypertension through Caveolin1 and CAVIN1. Liu J, et al. J Cell Mol Med, 2021 May. PMID 33755319, Free PMC Article
    3. CIRBP Ameliorates Neuronal Amyloid Toxicity via Antioxidative and Antiapoptotic Pathways in Primary Cortical Neurons. Su F, et al. Oxid Med Cell Longev, 2020. PMID 32184914, Free PMC Article
    4. Cold-inducible RNA-binding protein modulates atrial fibrillation onset by targeting multiple ion channels. Xie D, et al. Heart Rhythm, 2020 Jun. PMID 31918003
    5. Effects of hypothermia and cerebral ischemia on cold-inducible RNA-binding protein mRNA expression in rat brain. Liu A, et al. Brain Res, 2010 Aug 6. PMID 20546708

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Associations of cold-inducible RNA-binding protein with bacterial load, proinflammatory cytokines and mortality from pneumonia.
      Title: Associations of cold-inducible RNA-binding protein with bacterial load, proinflammatory cytokines and mortality from pneumonia.
    2. Upregulation of CIRP by its agonist prevents the development of heart failure in myocardial infarction rats.
      Title: Upregulation of CIRP by its agonist prevents the development of heart failure in myocardial infarction rats.
    3. Deficiency of cold-inducible RNA-binding protein exacerbated monocrotaline-induced pulmonary artery hypertension through Caveolin1 and CAVIN1.
      Title: Deficiency of cold-inducible RNA-binding protein exacerbated monocrotaline-induced pulmonary artery hypertension through Caveolin1 and CAVIN1.
    4. Cold-inducible RNA-binding protein modulates atrial fibrillation onset by targeting multiple ion channels.
      Title: Cold-inducible RNA-binding protein modulates atrial fibrillation onset by targeting multiple ion channels.
    5. Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase.
      Title: Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase.
    6. CIRBP Ameliorates Neuronal Amyloid Toxicity via Antioxidative and Antiapoptotic Pathways in Primary Cortical Neurons.
      Title: CIRBP Ameliorates Neuronal Amyloid Toxicity via Antioxidative and Antiapoptotic Pathways in Primary Cortical Neurons.
    7. Nerve regeneration in rat peripheral nerve allografts: Evaluation of cold-inducible RNA-binding protein in nerve storage and regeneration.
      Title: Nerve regeneration in rat peripheral nerve allografts: Evaluation of cold-inducible RNA-binding protein in nerve storage and regeneration.
    8. Enhanced cold-inducible RNA-binding protein in microglia aggravates neuronal injury by promoting the release of proinflammatory cytokines, which might be mediated through Brd2-NF-kappaB signals during deep hypothermic circulatory arrest.
      Title: A novel target to reduce microglial inflammation and neuronal damage after deep hypothermic circulatory arrest.
    9. cold temperature can induce an airway inflammatory response and excess mucus production via a CIRP-mediated increase in mRNA stability and protein translation
      Title: Cold-inducible RNA-binding protein mediates airway inflammation and mucus hypersecretion through a post-transcriptional regulatory mechanism under cold stress.
    10. therapeutic hypothermia exerts an important neuroprotective effects by up-regulating CIRP expression.
      Title: Therapeutic Hypothermia Enhances Cold-Inducible RNA-Binding Protein Expression and Inhibits Mitochondrial Apoptosis in a Rat Model of Cardiac Arrest.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small ribosomal subunit rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small ribosomal subunit rRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation repressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cold ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cold-inducible RNA-binding protein
    Names
    A18 hnRNP
    glycine-rich RNA-binding protein CIRP

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031147.4 → NP_112409.3  cold-inducible RNA-binding protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      O09069, O09148, P60825, Q61413
      UniProtKB/TrEMBL
      A6K8P8, Q6NT88
      Conserved Domains (1) summary
      cd12449
      Location:6 → 85
      RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

    RNA

    1. NR_172713.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007

    2. NR_172714.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      Related
      ENSRNOT00000162080.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10184515..10189623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241015.5 → XP_006241077.3  cold-inducible RNA-binding protein isoform X2

      UniProtKB/Swiss-Prot
      O09069, O09148, P60825, Q61413
      UniProtKB/TrEMBL
      A6K8P8, Q6NT88
      Conserved Domains (1) summary
      cd12449
      Location:6 → 85
      RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

    2. XM_063264303.1 → XP_063120373.1  cold-inducible RNA-binding protein isoform X1

      UniProtKB/TrEMBL
      A6K8P9, Q6NT88

    3. XM_039079945.2 → XP_038935873.1  cold-inducible RNA-binding protein isoform X1

      UniProtKB/TrEMBL
      A6K8P9, Q6NT88
      Conserved Domains (1) summary
      cd12449
      Location:6 → 85
      RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60825.1 GenPept UniProtKB/Swiss-Prot:P60825

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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