Cox6b1 cytochrome c oxidase subunit 6B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cox6b1provided by RGD
Official Full Name: cytochrome c oxidase subunit 6B1provided by RGD
Primary source: RGD:1584097
See related: EnsemblRapid:ENSRNOG00000024309 AllianceGenome:RGD:1584097
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cox6b
Summary: Predicted to be involved in substantia nigra development. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 7. Orthologous to human COX6B1 (cytochrome c oxidase subunit 6B1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 5203.7), Muscle (RPKM 3130.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (95002513..95011516, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (85875080..85884081, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (89075987..89084834, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

COX6B1 overexpression may reverse I/R-induced neuronal damage by increasing the viability of neurons, by decreasing the cytosolic levels of Ca2+ and by suppressing apoptosis.
Title: Overexpression of COX6B1 protects against I/R‑induced neuronal injury in rat hippocampal neurons.
COX6B1 protected cardiomyocytes from hypoxia/reoxygenation injury by reducing ROS production and cell apoptosis, during which reduction of the release of cytochrome C from mitochondria to cytosol was involved.
Title: COX6B1 relieves hypoxia/reoxygenation injury of neonatal rat cardiomyocytes by regulating mitochondrial function.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cox6b1 (e-PCR), detects polymorphism
- UniSTS:531501

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in oxidative phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex IV	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex IV	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome c oxidase subunit 6B1

Names: COX VIb-1; cytochrome c oxidase subunit VIb; cytochrome c oxidase, subunit VIb polypeptide 1

NP_001138745.1

EC 7.1.1.9

XP_006228857.1

EC 7.1.1.9

XP_038947145.1

EC 7.1.1.9

XP_063130482.1

EC 7.1.1.9

XP_063130488.1

EC 7.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145273.1 → NP_001138745.1 cytochrome c oxidase subunit 6B1

See identical proteins and their annotated locations for NP_001138745.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6A8X0, A6JA04

Conserved Domains (1) summary

cd00926
Location:8 → 85

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

95002513..95011516 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228795.3 → XP_006228857.1 cytochrome c oxidase subunit 6B1 isoform X1

See identical proteins and their annotated locations for XP_006228857.1

UniProtKB/TrEMBL

A0A8I6A8X0, A6JA04

Conserved Domains (1) summary

cd00926
Location:8 → 85

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
XM_039091217.2 → XP_038947145.1 cytochrome c oxidase subunit 6B1 isoform X2

UniProtKB/TrEMBL

A6JA04, D3ZSB0

Related

ENSRNOP00000030997.3, ENSRNOT00000032026.5

Conserved Domains (1) summary

cd00926
Location:8 → 70

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
XM_063274412.1 → XP_063130482.1 cytochrome c oxidase subunit 6B1 isoform X1

UniProtKB/TrEMBL

A0A8I6A8X0, A6JA04
XM_063274418.1 → XP_063130488.1 cytochrome c oxidase subunit 6B1 isoform X2

UniProtKB/TrEMBL

A6JA04, D3ZSB0