Ppp1r13l protein phosphatase 1, regulatory subunit 13 like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp1r13lprovided by RGD
Official Full Name: protein phosphatase 1, regulatory subunit 13 likeprovided by RGD
Primary source: RGD:1593681
See related: EnsemblRapid:ENSRNOG00000025350 AllianceGenome:RGD:1593681
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Involved in positive regulation of cell differentiation. Predicted to be located in cell junction; cytosol; and intercellular bridge. Orthologous to human PPP1R13L (protein phosphatase 1 regulatory subunit 13 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 25.2), Lung (RPKM 6.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88139000..88158714)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (79010997..79030714)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80271288..80290946)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D1Rat177 (e-PCR), detects polymorphism
- UniSTS:118541

BF400777 (e-PCR)
- UniSTS:245032

Ckmm (e-PCR), detects polymorphism
- UniSTS:238130

D1Got80 (e-PCR)
- UniSTS:112448

RH94390 (e-PCR)
- UniSTS:119638

RH129012 (e-PCR)
- UniSTS:212320

D1Got81 (e-PCR)
- UniSTS:113254

RH138712 (e-PCR)
- UniSTS:220799

RH138979 (e-PCR)
- UniSTS:221065

PMC125755P1 (e-PCR)
- UniSTS:270514

D1Bda2 (e-PCR)
- UniSTS:240336

RH134037 (e-PCR)
- UniSTS:217319

RH142672 (e-PCR)
- UniSTS:231919

RH144210 (e-PCR)
- UniSTS:233455

BE107128 (e-PCR)
- UniSTS:246771

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac right ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal-level homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventricular cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: relA-associated inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427130.1 → NP_001414059.1 relA-associated inhibitor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

F1LW07

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

88139000..88158714

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274161.1 → XP_063130231.1 relA-associated inhibitor isoform X1
XM_063274155.1 → XP_063130225.1 relA-associated inhibitor isoform X1
XM_063274166.1 → XP_063130236.1 relA-associated inhibitor isoform X1
XM_063274170.1 → XP_063130240.1 relA-associated inhibitor isoform X3

Related

ENSRNOP00000100541.1, ENSRNOT00000134210.1
XM_006228495.4 → XP_006228557.1 relA-associated inhibitor isoform X2

See identical proteins and their annotated locations for XP_006228557.1

Related

ENSRNOP00000050977.5, ENSRNOT00000047105.6

Conserved Domains (4) summary

cd11952
Location:773 → 829

SH3_iASPP; Src Homology 3 (SH3) domain of Inhibitor of ASPP protein (iASPP)

cd00204
Location:638 → 760

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:643 → 734

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:643 → 669

ANK; ANK repeat [structural motif]