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    Gdpd2 glycerophosphodiester phosphodiesterase domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302421, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gdpd2provided by RGD
    Official Full Name
    glycerophosphodiester phosphodiesterase domain containing 2provided by RGD
    Primary source
    RGD:1560780
    See related
    EnsemblRapid:ENSRNOG00000002800 AllianceGenome:RGD:1560780
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560780
    Summary
    Predicted to enable glycerophosphodiester phosphodiesterase activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within actin filament organization and positive regulation of osteoblast differentiation. Predicted to be located in actin filament and lamellipodium. Predicted to be active in plasma membrane. Orthologous to human GDPD2 (glycerophosphodiester phosphodiesterase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 175.3), Brain (RPKM 17.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gdpd2 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (69866395..69875419)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (65826273..65835361)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (70563381..70572295)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099344 Neighboring gene kinesin family member 4A Neighboring gene transfer RNA phenylalanine (anticodon GAA) 8 Neighboring gene discs large MAGUK scaffold protein 3 Neighboring gene testis expressed 11 Neighboring gene sarcoglycan, beta, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel membrane protein containing glycerophosphodiester phosphodiesterase motif is transiently expressed during osteoblast differentiation. Yanaka N, et al. J Biol Chem, 2003 Oct 31. PMID 12933806
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glycerophosphodiester phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycerophosphoinositol inositolphosphodiesterase GDPD2
    NP_001100414.1
    XP_006257126.1
    XP_038955521.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106944.1 → NP_001100414.1  glycerophosphoinositol inositolphosphodiesterase GDPD2

      See identical proteins and their annotated locations for NP_001100414.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473966
      UniProtKB/TrEMBL
      A6IQ87, D3Z9K9
      Related
      ENSRNOP00000003772.3, ENSRNOT00000003772.7
      Conserved Domains (1) summary
      cl14615
      Location:198 → 499
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      69866395..69875419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099593.2 → XP_038955521.1  glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1

      UniProtKB/TrEMBL
      A6IQ87, D3Z9K9
      Conserved Domains (1) summary
      cl14615
      Location:198 → 499
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    2. XM_006257064.5 → XP_006257126.1  glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1

      See identical proteins and their annotated locations for XP_006257126.1

      UniProtKB/TrEMBL
      A6IQ87, D3Z9K9
      Conserved Domains (1) summary
      cl14615
      Location:198 → 499
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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