Slc52a3 solute carrier family 52 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc52a3provided by RGD
Official Full Name: solute carrier family 52 member 3provided by RGD
Primary source: RGD:1304644
See related: EnsemblRapid:ENSRNOG00000005132 AllianceGenome:RGD:1304644
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rft2; rRFT2; RGD1304644
Summary: Enables riboflavin transmembrane transporter activity. Involved in riboflavin transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in Brown-Vialetto-Van Laere syndrome 1 and Fazio-Londe disease. Orthologous to human SLC52A3 (solute carrier family 52 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 37.3), Testes (RPKM 23.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (160959233..160976170)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (140498924..140515845)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (147503266..147517935)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The function and inhibition profile suggested the involvement of Slc52a3 in riboflavin transport at the inner BRB, and this is supported by expression and knockdown analysis of rRFVT2 (Slc52a2) and rRFVT3 (Slc52a3) in TR-iBRB2 cells.
Title: Blood-to-retina transport of riboflavin via RFVTs at the inner blood-retinal barrier.
Intestinal riboflavin uptake process undergoes differentiation-dependent upregulation and suggest that this is mediated (at least in part) via transcriptional mechanisms of Rft1 and Rft2.
Title: Differentiation-dependent regulation of intestinal vitamin B(2) uptake: studies utilizing human-derived intestinal epithelial Caco-2 cells and native rat intestine.
results indicate that riboflavin transporter 2(RFT2) is a transporter involved in the epithelial uptake of riboflavin in the small intestine for its nutritional utilization
Title: Functional characteristics of the human ortholog of riboflavin transporter 2 and riboflavin-responsive expression of its rat ortholog in the small intestine indicate its involvement in riboflavin absorption.
RFT2 may play a role in the intestinal absorption of riboflavin.
Title: Identification and functional characterization of rat riboflavin transporter 2.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables riboflavin transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables riboflavin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables riboflavin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables riboflavin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to heat	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in flavin adenine dinucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in flavin adenine dinucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in riboflavin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in riboflavin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in riboflavin transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in riboflavin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in riboflavin transport	IEA Inferred from Electronic Annotation more info
involved_in riboflavin transport	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 52, riboflavin transporter, member 3

Names: riboflavin transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037198.2 → NP_001032275.2 solute carrier family 52, riboflavin transporter, member 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3

Related

ENSRNOP00000006828.4, ENSRNOT00000006828.6
NM_001434072.1 → NP_001421001.1 solute carrier family 52, riboflavin transporter, member 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3
NM_001434073.1 → NP_001421002.1 solute carrier family 52, riboflavin transporter, member 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3
NM_001434074.1 → NP_001421003.1 solute carrier family 52, riboflavin transporter, member 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

160959233..160976170

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283821.1 → XP_063139891.1 solute carrier family 52, riboflavin transporter, member 3 isoform X1

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3
XM_039105052.2 → XP_038960980.1 solute carrier family 52, riboflavin transporter, member 3 isoform X1

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3

Conserved Domains (1) summary

pfam06237
Location:292 → 387

DUF1011; Protein of unknown function (DUF1011)
XM_006235238.5 → XP_006235300.1 solute carrier family 52, riboflavin transporter, member 3 isoform X1

See identical proteins and their annotated locations for XP_006235300.1

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3

Conserved Domains (1) summary

pfam06237
Location:292 → 387

DUF1011; Protein of unknown function (DUF1011)
XM_063283822.1 → XP_063139892.1 solute carrier family 52, riboflavin transporter, member 3 isoform X2
XM_063283816.1 → XP_063139886.1 solute carrier family 52, riboflavin transporter, member 3 isoform X1

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3
XM_063283815.1 → XP_063139885.1 solute carrier family 52, riboflavin transporter, member 3 isoform X1

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3
XM_063283818.1 → XP_063139888.1 solute carrier family 52, riboflavin transporter, member 3 isoform X1

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3
XM_063283819.1 → XP_063139889.1 solute carrier family 52, riboflavin transporter, member 3 isoform X1

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3
XM_063283814.1 → XP_063139884.1 solute carrier family 52, riboflavin transporter, member 3 isoform X1

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3
XM_063283817.1 → XP_063139887.1 solute carrier family 52, riboflavin transporter, member 3 isoform X1

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3
XM_063283813.1 → XP_063139883.1 solute carrier family 52, riboflavin transporter, member 3 isoform X1

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3
XM_063283820.1 → XP_063139890.1 solute carrier family 52, riboflavin transporter, member 3 isoform X1

UniProtKB/Swiss-Prot

Q4FZU9

UniProtKB/TrEMBL

A6KHL8, G3V6N3