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    Foxc1 forkhead box C1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364706, updated on 4-Jan-2025

    Summary

    Official Symbol
    Foxc1provided by RGD
    Official Full Name
    forkhead box C1provided by RGD
    Primary source
    RGD:1589718
    See related
    EnsemblRapid:ENSRNOG00000089468 AllianceGenome:RGD:1589718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; circulatory system development; and collagen fibril organization. Predicted to be located in cytosol; heterochromatin; and nucleoplasm. Human ortholog(s) of this gene implicated in Axenfeld-Rieger syndrome; Axenfeld-Rieger syndrome type 3; anterior segment dysgenesis 3; and glaucoma. Orthologous to human FOXC1 (forkhead box C1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See Foxc1 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (32840119..32844100, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (32631379..32635361, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (33947501..33951484, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348555 Neighboring gene GDP-mannose 4, 6-dehydratase Neighboring gene uncharacterized LOC134482705 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA binding, bending  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables promoter-specific chromatin binding  
    enables sequence-specific DNA binding  
    enables transcription cis-regulatory region binding  
    Items 1 - 25 of 63
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway  
    involved_in anatomical structure morphogenesis  
    acts_upstream_of apoptotic process involved in outflow tract morphogenesis  
    acts_upstream_of_or_within artery morphogenesis  
    involved_in biological_process  
    acts_upstream_of_or_within blood vessel development  
    acts_upstream_of_or_within blood vessel diameter maintenance  
    acts_upstream_of_or_within blood vessel remodeling  
    acts_upstream_of_or_within brain development  
    acts_upstream_of_or_within camera-type eye development  
    acts_upstream_of_or_within cardiac muscle cell proliferation  
    involved_in cell differentiation  
    involved_in cell migration  
    involved_in cell population proliferation  
    involved_in cellular response to chemokine  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cerebellum development  
    involved_in chemokine-mediated signaling pathway  
    acts_upstream_of_or_within collagen fibril organization  
    acts_upstream_of_or_within embryonic heart tube development  
    involved_in endochondral ossification  
    acts_upstream_of_or_within eye development  
    acts_upstream_of_or_within germ cell migration  
    involved_in glomerular epithelium development  
    acts_upstream_of_or_within glycosaminoglycan metabolic process  
    acts_upstream_of_or_within heart development  
    acts_upstream_of_or_within heart morphogenesis  
    acts_upstream_of_or_within in utero embryonic development  
    acts_upstream_of_or_within kidney development  
    acts_upstream_of_or_within lacrimal gland development  
    acts_upstream_of_or_within lymph vessel development  
    involved_in maintenance of lens transparency  
    involved_in mesenchymal cell development  
    acts_upstream_of_or_within mesenchymal cell differentiation  
    involved_in negative regulation of angiogenesis  
    acts_upstream_of_or_within negative regulation of apoptotic process involved in outflow tract morphogenesis  
    involved_in negative regulation of lymphangiogenesis  
    involved_in negative regulation of mitotic cell cycle  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within neural crest cell development  
    involved_in odontogenesis of dentin-containing tooth  
    acts_upstream_of_or_within ossification  
    acts_upstream_of_or_within ovarian follicle development  
    acts_upstream_of_or_within paraxial mesoderm formation  
    involved_in paraxial mesoderm formation  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of hematopoietic progenitor cell differentiation  
    involved_in positive regulation of hematopoietic stem cell differentiation  
    involved_in positive regulation of keratinocyte differentiation  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of organ growth  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within skeletal system development  
    involved_in somitogenesis  
    acts_upstream_of_or_within ureteric bud development  
    acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    acts_upstream_of_or_within ventricular cardiac muscle tissue morphogenesis  
    Items 1 - 25 of 63
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    located_in heterochromatin  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134338.3NP_599165.1  forkhead box protein C1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6GKJ4, A6J7K0
      Related
      ENSRNOP00000111803.1, ENSRNOT00000133281.1
      Conserved Domains (1) summary
      smart00339
      Location:78166
      FH; FORKHEAD

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      32840119..32844100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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