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    Aoc3 amine oxidase, copper containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29473, updated on 4-Jan-2025

    Summary

    Official Symbol
    Aoc3provided by RGD
    Official Full Name
    amine oxidase, copper containing 3provided by RGD
    Primary source
    RGD:62058
    See related
    AllianceGenome:RGD:62058
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SSAO
    Summary
    Enables identical protein binding activity and primary methylamine oxidase activity. Involved in several processes, including eating behavior; leukocyte migration involved in inflammatory response; and positive regulation of D-glucose transmembrane transport. Located in extracellular space. Used to study aortic aneurysm; obesity; type 2 diabetes mellitus; and uveitis. Biomarker of intracranial aneurysm. Orthologous to human AOC3 (amine oxidase copper containing 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 470.0), Heart (RPKM 277.5) and 7 other tissues See more
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    Genomic context

    See Aoc3 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86773018..86780961)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86272757..86280702)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89251370..89259313)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 3 Neighboring gene amine oxidase, copper containing 2, pseudogene 1 Neighboring gene uncharacterized LOC134480877 Neighboring gene U1 spliceosomal RNA Neighboring gene glucose-6-phosphatase catalytic subunit 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aliphatic amine oxidase activity  
    enables calcium ion binding  
    enables copper ion binding  
    enables copper ion binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables primary methylamine oxidase activity PubMed 
    NOT enables primary methylamine oxidase activity  
    enables primary methylamine oxidase activity  
    enables primary methylamine oxidase activity PubMed 
    enables protein heterodimerization activity  
    enables quinone binding  
    enables quinone binding PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in cell surface  
    located_in cell surface PubMed 
    located_in cytoplasm  
    is_active_in early endosome  
    located_in early endosome  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in extracellular space PubMed 
    located_in membrane  
    located_in membrane PubMed 
    located_in microvillus  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    amine oxidase [copper-containing] 3
    Names
    VAP-1
    VP97
    copper amine oxidase
    membrane primary amine oxidase
    semicarbazide-sensitive amine oxidase
    vascular adhesion protein 1
    NP_113770.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031582.3NP_113770.2  amine oxidase [copper-containing] 3

      See identical proteins and their annotated locations for NP_113770.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O08590, Q497D2, Q5R1T5
      UniProtKB/TrEMBL
      A6HJB0
      Conserved Domains (4) summary
      COG3733
      Location:40722
      TynA; Cu2+-containing amine oxidase [Secondary metabolites biosynthesis, transport and catabolism]
      pfam01179
      Location:315721
      Cu_amine_oxid; Copper amine oxidase, enzyme domain
      pfam02727
      Location:66152
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:169269
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86773018..86780961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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