Cops3 COP9 signalosome subunit 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cops3provided by RGD
Official Full Name: COP9 signalosome subunit 3provided by RGD
Primary source: RGD:1303002
See related: EnsemblRapid:ENSRNOG00000053943 AllianceGenome:RGD:1303002
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in protein deneddylation; regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of COP9 signalosome. Orthologous to human COPS3 (COP9 signalosome subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 480.7), Heart (RPKM 340.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (45117664..45151868, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (44618115..44652807, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (46182680..46206083, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129531 (e-PCR)
- UniSTS:212833

RH137040 (e-PCR)
- UniSTS:219129

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in protein deneddylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info
part_of COP9 signalosome	IEA Inferred from Electronic Annotation more info
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: COP9 signalosome complex subunit 3

Names: COP9 (constitutive photomorphogenic) homolog, subunit 3; SGN3; signalosome subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004200.1 → NP_001004200.1 COP9 signalosome complex subunit 3

See identical proteins and their annotated locations for NP_001004200.1

Status: PROVISIONAL

Source sequence(s)

BC079143

UniProtKB/Swiss-Prot

Q68FW9

UniProtKB/TrEMBL

A0A8I5Y8F4

Related

ENSRNOP00000069208.1, ENSRNOT00000091471.3

Conserved Domains (1) summary

pfam01399
Location:259 → 362

PCI; PCI domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

45117664..45151868 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085398.2 → XP_038941326.2 COP9 signalosome complex subunit 3 isoform X1

UniProtKB/TrEMBL

A0A8I5Y8F4

Related

ENSRNOP00000109659.1, ENSRNOT00000168377.1
XM_039085399.2 → XP_038941327.1 COP9 signalosome complex subunit 3 isoform X1

UniProtKB/TrEMBL

A0A8I5Y8F4

Conserved Domains (1) summary

pfam01399
Location:239 → 342

PCI; PCI domain
XM_063268611.1 → XP_063124681.1 COP9 signalosome complex subunit 3 isoform X1

UniProtKB/TrEMBL

A0A8I5Y8F4
XM_017597079.3 → XP_017452568.1 COP9 signalosome complex subunit 3 isoform X3

Conserved Domains (1) summary

pfam01399
Location:129 → 232

PCI; PCI domain
XM_063268612.1 → XP_063124682.1 COP9 signalosome complex subunit 3 isoform X2