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    Crhbp corticotropin releasing hormone binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29625, updated on 9-Dec-2024

    Summary

    Official Symbol
    Crhbpprovided by RGD
    Official Full Name
    corticotropin releasing hormone binding proteinprovided by RGD
    Primary source
    RGD:2403
    See related
    EnsemblRapid:ENSRNOG00000017890 AllianceGenome:RGD:2403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crfbp
    Summary
    Enables corticotropin-releasing hormone binding activity and peptide binding activity. Involved in several processes, including cellular response to cocaine; cellular response to estradiol stimulus; and cellular response to estrogen stimulus. Located in several cellular components, including axon; cytoplasmic vesicle; and perikaryon. Biomarker of depressive disorder; obesity; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human CRHBP (corticotropin releasing hormone binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 45.4) See more
    Orthologs
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    Genomic context

    See Crhbp in Genome Data Viewer
    Location:
    2q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (28427139..28439446, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (26692403..26704710, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (25141471..25153334, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene angiogenic factor with G patch and FHA domains 1 Neighboring gene small nucleolar RNA SNORD78 Neighboring gene uncharacterized LOC134485818 Neighboring gene S100 calcium binding protein Z Neighboring gene F2R like trypsin receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 56
    Process Evidence Code Pubs
    involved_in behavioral response to ethanol  
    involved_in behavioral response to ethanol  
    involved_in behavioral response to ethanol  
    involved_in cellular response to cAMP  
    involved_in cellular response to cAMP  
    involved_in cellular response to calcium ion  
    involved_in cellular response to calcium ion  
    involved_in cellular response to cocaine PubMed 
    involved_in cellular response to estradiol stimulus PubMed 
    involved_in cellular response to estradiol stimulus  
    involved_in cellular response to estradiol stimulus  
    involved_in cellular response to estrogen stimulus PubMed 
    involved_in cellular response to estrogen stimulus  
    involved_in cellular response to estrogen stimulus  
    involved_in cellular response to gonadotropin-releasing hormone  
    involved_in cellular response to gonadotropin-releasing hormone  
    involved_in cellular response to immobilization stress PubMed 
    involved_in cellular response to potassium ion  
    involved_in cellular response to potassium ion  
    involved_in cellular response to potassium ion  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to xenobiotic stimulus  
    involved_in cellular response to xenobiotic stimulus  
    involved_in female pregnancy  
    involved_in female pregnancy  
    involved_in hormone metabolic process PubMed 
    acts_upstream_of_or_within hormone metabolic process  
    involved_in hormone-mediated signaling pathway  
    involved_in hormone-mediated signaling pathway  
    involved_in hormone-mediated signaling pathway  
    involved_in hormone-mediated signaling pathway  
    involved_in inflammatory response  
    involved_in inflammatory response  
    involved_in inflammatory response  
    involved_in maternal aggressive behavior  
    involved_in maternal aggressive behavior  
    involved_in negative regulation of corticotropin secretion  
    involved_in negative regulation of corticotropin secretion PubMed 
    involved_in negative regulation of corticotropin secretion  
    involved_in negative regulation of corticotropin secretion  
    involved_in negative regulation of corticotropin-releasing hormone receptor activity  
    involved_in negative regulation of corticotropin-releasing hormone receptor activity  
    involved_in regulated exocytosis  
    involved_in regulated exocytosis  
    involved_in regulated exocytosis  
    involved_in regulation of NMDA receptor activity  
    involved_in regulation of NMDA receptor activity  
    involved_in regulation of cellular response to stress  
    involved_in regulation of cellular response to stress  
    involved_in regulation of corticotropin secretion  
    involved_in regulation of corticotropin secretion  
    involved_in synaptic transmission, dopaminergic PubMed 
    involved_in synaptic transmission, dopaminergic  
    involved_in synaptic transmission, dopaminergic  
    Items 1 - 25 of 56
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus  
    NOT located_in Golgi apparatus  
    located_in axon terminus PubMed 
    located_in dendrite PubMed 
    located_in dense core granule PubMed 
    NOT located_in endoplasmic reticulum  
    NOT located_in endoplasmic reticulum  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in extracellular space  
    located_in microtubule PubMed 
    located_in multivesicular body PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in perikaryon PubMed 
    located_in secondary lysosome PubMed 
    located_in secretory granule  
    located_in secretory granule  
    located_in secretory granule  
    located_in varicosity PubMed 
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    corticotropin-releasing factor-binding protein
    Names
    CRF-BP
    CRF-binding protein
    CRH-BP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139183.2NP_631922.1  corticotropin-releasing factor-binding protein precursor

      See identical proteins and their annotated locations for NP_631922.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P24388
      UniProtKB/TrEMBL
      F7EU31, O35761
      Related
      ENSRNOP00000024191.3, ENSRNOT00000024191.6
      Conserved Domains (1) summary
      pfam05428
      Location:1307
      CRF-BP; Corticotropin-releasing factor binding protein (CRF-BP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      28427139..28439446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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