U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25513, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pik3r1provided by RGD
    Official Full Name
    phosphoinositide-3-kinase regulatory subunit 1provided by RGD
    Primary source
    RGD:3329
    See related
    EnsemblRapid:ENSRNOG00000018903 AllianceGenome:RGD:3329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PI3KA
    Summary
    Enables several functions, including 1-phosphatidylinositol-3-kinase regulator activity; calmodulin binding activity; and enzyme binding activity. Contributes to 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; regulation of protein metabolic process; and response to dexamethasone. Part of phosphatidylinositol 3-kinase complex. Used to study hypertension and portal hypertension. Biomarker of hepatocellular carcinoma; hypertension; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; agammaglobulinemia 7; astroblastoma; endometrial cancer (multiple); and immunodeficiency 36. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 301.4), Lung (RPKM 250.0) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pik3r1 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (34612946..34697660, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (32878942..32963668, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (31742326..31826882, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100691 Neighboring gene uncharacterized LOC102556051 Neighboring gene histidine-rich glycoprotein-like Neighboring gene uncharacterized LOC108350224

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 47
    Function Evidence Code Pubs
    contributes_to 1-phosphatidylinositol-3-kinase activity PubMed 
    enables 1-phosphatidylinositol-3-kinase activity PubMed 
    enables 1-phosphatidylinositol-3-kinase regulator activity  
    enables 1-phosphatidylinositol-3-kinase regulator activity PubMed 
    enables 1-phosphatidylinositol-3-kinase regulator activity  
    enables 1-phosphatidylinositol-3-kinase regulator activity  
    enables ATPase binding PubMed 
    enables ErbB-3 class receptor binding  
    enables ErbB-3 class receptor binding  
    enables ErbB-3 class receptor binding  
    enables calmodulin binding PubMed 
    enables insulin binding  
    enables insulin binding  
    enables insulin receptor binding  
    enables insulin receptor binding  
    enables insulin receptor binding  
    enables insulin receptor substrate binding  
    enables insulin receptor substrate binding PubMed 
    enables insulin receptor substrate binding  
    enables insulin receptor substrate binding  
    enables insulin-like growth factor receptor binding  
    enables insulin-like growth factor receptor binding  
    enables insulin-like growth factor receptor binding  
    enables kinase activator activity  
    enables kinase activator activity  
    enables neurotrophin TRKA receptor binding  
    enables neurotrophin TRKA receptor binding  
    enables nuclear estrogen receptor binding PubMed 
    enables phosphatidylinositol 3-kinase regulator activity  
    enables phosphatidylinositol 3-kinase regulator activity  
    enables phosphatidylinositol 3-kinase regulator activity  
    enables phosphatidylinositol 3-kinase regulatory subunit binding  
    enables phosphatidylinositol 3-kinase regulatory subunit binding  
    enables phosphoprotein binding PubMed 
    enables phosphotyrosine residue binding  
    enables phosphotyrosine residue binding  
    enables platelet-derived growth factor receptor binding PubMed 
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein kinase binding PubMed 
    enables protein phosphatase binding  
    enables protein phosphatase binding  
    enables receptor tyrosine kinase binding PubMed 
    enables signaling receptor binding PubMed 
    enables ubiquitin protein ligase binding PubMed 
    Items 1 - 25 of 47
    Items 1 - 25 of 121
    Process Evidence Code Pubs
    involved_in B cell differentiation  
    acts_upstream_of_or_within B cell differentiation  
    involved_in T follicular helper cell differentiation  
    involved_in cellular response to UV  
    acts_upstream_of_or_within cellular response to UV  
    involved_in cellular response to fatty acid PubMed 
    involved_in cellular response to insulin stimulus PubMed 
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to insulin stimulus  
    involved_in cytokine-mediated signaling pathway  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in glucose metabolic process PubMed 
    involved_in growth hormone receptor signaling pathway  
    involved_in growth hormone receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway PubMed 
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway PubMed 
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in interleukin-18-mediated signaling pathway  
    involved_in interleukin-18-mediated signaling pathway  
    involved_in intracellular glucose homeostasis  
    involved_in intracellular glucose homeostasis  
    involved_in intracellular glucose homeostasis  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage  
    involved_in myeloid leukocyte migration  
    acts_upstream_of myeloid leukocyte migration  
    involved_in natural killer cell mediated cytotoxicity  
    involved_in natural killer cell mediated cytotoxicity  
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of blood pressure PubMed 
    acts_upstream_of_or_within negative regulation of cell adhesion  
    involved_in negative regulation of cell-cell adhesion PubMed 
    involved_in negative regulation of cell-matrix adhesion  
    acts_upstream_of_or_within negative regulation of cell-matrix adhesion  
    involved_in negative regulation of heart rate PubMed 
    involved_in negative regulation of muscle cell apoptotic process PubMed 
    involved_in negative regulation of osteoclast differentiation  
    acts_upstream_of_or_within negative regulation of osteoclast differentiation  
    involved_in negative regulation of proteolysis PubMed 
    involved_in negative regulation of smooth muscle cell proliferation PubMed 
    involved_in negative regulation of stress fiber assembly  
    involved_in negative regulation of stress fiber assembly  
    involved_in osteoclast differentiation  
    acts_upstream_of osteoclast differentiation  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphatidylinositol metabolic process PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process  
    involved_in positive regulation of RNA splicing  
    involved_in positive regulation of RNA splicing  
    involved_in positive regulation of RNA splicing  
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of endoplasmic reticulum unfolded protein response  
    involved_in positive regulation of endoplasmic reticulum unfolded protein response  
    involved_in positive regulation of endoplasmic reticulum unfolded protein response  
    involved_in positive regulation of filopodium assembly  
    involved_in positive regulation of filopodium assembly  
    involved_in positive regulation of focal adhesion disassembly  
    involved_in positive regulation of focal adhesion disassembly  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of lamellipodium assembly  
    involved_in positive regulation of lamellipodium assembly  
    involved_in positive regulation of leukocyte migration  
    acts_upstream_of_or_within positive regulation of leukocyte migration  
    involved_in positive regulation of myoblast differentiation PubMed 
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of synapse assembly PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of tumor necrosis factor production  
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production  
    involved_in protein import into nucleus  
    acts_upstream_of_or_within protein import into nucleus  
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in regulation of protein localization to plasma membrane  
    acts_upstream_of_or_within regulation of protein localization to plasma membrane  
    acts_upstream_of_or_within regulation of stress fiber assembly  
    involved_in regulation of toll-like receptor 4 signaling pathway  
    involved_in regulation of toll-like receptor 4 signaling pathway  
    involved_in response to amino acid PubMed 
    involved_in response to cAMP PubMed 
    involved_in response to dexamethasone PubMed 
    involved_in response to endoplasmic reticulum stress  
    involved_in response to endoplasmic reticulum stress  
    involved_in response to endoplasmic reticulum stress  
    involved_in response to estradiol PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to fatty acid PubMed 
    involved_in response to fructose PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to growth factor PubMed 
    involved_in response to insulin PubMed 
    involved_in response to iron(II) ion PubMed 
    involved_in response to nutrient PubMed 
    involved_in response to progesterone PubMed 
    involved_in response to testosterone PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in response to yeast PubMed 
    involved_in transcription by RNA polymerase II  
    acts_upstream_of transcription by RNA polymerase II  
    Items 1 - 25 of 121
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    located_in cell-cell junction  
    located_in cell-cell junction  
    located_in cis-Golgi network  
    located_in cis-Golgi network  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in membrane  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear endoplasmic reticulum membrane  
    located_in perinuclear endoplasmic reticulum membrane  
    located_in perinuclear region of cytoplasm  
    part_of phosphatidylinositol 3-kinase complex PubMed 
    part_of phosphatidylinositol 3-kinase complex PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA  
    part_of phosphatidylinositol 3-kinase complex, class IA  
    part_of phosphatidylinositol 3-kinase complex, class IA  
    part_of phosphatidylinositol 3-kinase complex, class IA  
    part_of protein-containing complex PubMed 
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    phosphatidylinositol 3-kinase regulatory subunit alpha
    Names
    PI3-kinase p85 subunit alpha
    PI3-kinase regulatory subunit alpha
    PI3-kinase subunit p85-alpha
    PI3K regulatory subunit alpha
    Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50)
    Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
    phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
    phosphatidylinositol 3-kinase p85 alpha
    phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
    phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
    ptdIns-3-kinase p85-alpha
    ptdIns-3-kinase regulatory subunit alpha
    ptdIns-3-kinase regulatory subunit p85-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013005.3NP_037137.2  phosphatidylinositol 3-kinase regulatory subunit alpha

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O55085, P70544, Q63787, Q63790
      UniProtKB/TrEMBL
      A6I5C4, F1LNG5
      Conserved Domains (5) summary
      cd09930
      Location:617720
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:328435
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11910
      Location:579
      SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12924
      Location:440600
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      cd04388
      Location:114302
      RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      34612946..34697660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760659.4XP_008758881.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

      See identical proteins and their annotated locations for XP_008758881.1

      UniProtKB/TrEMBL
      A6I5C5
      Related
      ENSRNOP00000067155.2, ENSRNOT00000075057.3
      Conserved Domains (4) summary
      cd09930
      Location:317420
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:28135
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12924
      Location:140300
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      pfam16454
      Location:139298
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
    2. XM_006231868.5XP_006231930.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_006231930.1

      UniProtKB/TrEMBL
      A6I5C6, M0RC47
      Related
      ENSRNOP00000104471.1, ENSRNOT00000159310.1
      Conserved Domains (4) summary
      cd09930
      Location:347450
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:58165
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12924
      Location:170330
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      pfam16454
      Location:169328
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
    External link. Please review our privacy policy.