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    Hoxa5 homeo box A5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79241, updated on 9-Dec-2024

    Summary

    Symbol
    Hoxa5provided by RGD
    Full Name
    homeo box A5provided by RGD
    Primary source
    RGD:620609
    See related
    EnsemblRapid:ENSRNOG00000047951 AllianceGenome:RGD:620609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation of angiogenesis; regulation of gene expression; and regulation of myeloid cell differentiation. Predicted to act upstream of or within several processes, including intestinal epithelial cell maturation; mammary gland development; and respiratory system development. Predicted to be active in nucleus. Orthologous to human HOXA5 (homeobox A5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 90.6), Lung (RPKM 88.9) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Hoxa5 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (82632958..82636851, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (81302341..81306234, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 Unlocalized Scaffold NW_007906169.1 (71788..76194, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene homeobox A3 Neighboring gene uncharacterized LOC120102276 Neighboring gene homeobox A3 like 1 Neighboring gene homeo box A4 Neighboring gene Hoxa cluster antisense RNA 3 Neighboring gene homeobox A6 Neighboring gene homeobox A7

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification  
    acts_upstream_of_or_within anterior/posterior pattern specification  
    acts_upstream_of_or_within bronchiole development  
    acts_upstream_of_or_within cartilage morphogenesis  
    acts_upstream_of_or_within cell migration  
    acts_upstream_of_or_within cell-cell signaling involved in mammary gland development  
    involved_in embryonic skeletal system development  
    acts_upstream_of_or_within embryonic skeletal system development  
    acts_upstream_of_or_within embryonic skeletal system morphogenesis  
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis  
    acts_upstream_of_or_within intestinal epithelial cell maturation  
    acts_upstream_of_or_within lobar bronchus epithelium development  
    acts_upstream_of_or_within lung alveolus development  
    acts_upstream_of_or_within lung development  
    acts_upstream_of_or_within lung goblet cell differentiation  
    acts_upstream_of_or_within lung-associated mesenchyme development  
    acts_upstream_of_or_within mammary gland alveolus development  
    acts_upstream_of_or_within mammary gland epithelial cell differentiation  
    acts_upstream_of_or_within mesenchymal-epithelial cell signaling  
    acts_upstream_of_or_within morphogenesis of an epithelium  
    acts_upstream_of_or_within multicellular organism growth  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of erythrocyte differentiation  
    involved_in negative regulation of erythrocyte differentiation  
    acts_upstream_of_or_within pattern specification process  
    involved_in pattern specification process PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of myeloid cell differentiation  
    involved_in positive regulation of myeloid cell differentiation  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of mammary gland epithelial cell proliferation  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system  
    acts_upstream_of_or_within respiratory system process  
    acts_upstream_of_or_within skeletal system development  
    acts_upstream_of_or_within thyroid gland development  
    acts_upstream_of_or_within trachea cartilage morphogenesis  
    acts_upstream_of_or_within trachea morphogenesis  
    Items 1 - 25 of 44
    Component Evidence Code Pubs
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    homeobox protein Hox-A5
    Names
    homeobox protein Hox-1.3
    homeobox protein Hox-A5-like
    hox-1.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024389.1NP_077365.1  homeobox protein Hox-A5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      M0R5H2
      Related
      ENSRNOP00000064639.2, ENSRNOT00000074167.4
      Conserved Domains (1) summary
      pfam00046
      Location:310363
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      82632958..82636851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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