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    Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299739, updated on 9-Dec-2024

    Summary

    Symbol
    Ndufa12provided by RGD
    Full Name
    NADH:ubiquinone oxidoreductase subunit A12provided by RGD
    Primary source
    RGD:1311462
    See related
    EnsemblRapid:ENSRNOG00000007407 AllianceGenome:RGD:1311462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311462
    Summary
    Predicted to be involved in mitochondrial ATP synthesis coupled electron transport and response to oxidative stress. Predicted to be located in cytosol and mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 23. Orthologous to human NDUFA12 (NADH:ubiquinone oxidoreductase subunit A12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 2939.1), Muscle (RPKM 1716.2) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Ndufa12 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (30658316..30685302)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (28771330..28798316)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (35125516..35163182)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene nuclear receptor subfamily 2, group C, member 1 Neighboring gene U4 spliceosomal RNA Neighboring gene transmembrane and coiled-coil domain family 3 Neighboring gene uncharacterized LOC102554269 Neighboring gene uncharacterized LOC134479860

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytosol  
    located_in mitochondrial inner membrane  
    located_in mitochondrion  
    part_of respiratory chain complex I  
    part_of respiratory chain complex I  

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
    Names
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12-like
    NP_001100251.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106781.2NP_001100251.2  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

      See identical proteins and their annotated locations for NP_001100251.2

      Status: VALIDATED

      Source sequence(s)
      BF555697, BG671355, BQ205274
      UniProtKB/TrEMBL
      A6IG10, F1LXA0
      Related
      ENSRNOP00000010117.7, ENSRNOT00000010117.7
      Conserved Domains (1) summary
      pfam05071
      Location:37137
      NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      30658316..30685302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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