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    Srl sarcalumenin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302948, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srlprovided by RGD
    Official Full Name
    sarcalumeninprovided by RGD
    Primary source
    RGD:1306564
    See related
    EnsemblRapid:ENSRNOG00000005269 AllianceGenome:RGD:1306564
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in store-operated calcium entry. Predicted to act upstream of or within response to muscle activity involved in regulation of muscle adaptation. Predicted to be located in membrane. Orthologous to human SRL (sarcalumenin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 2273.6) and Heart (RPKM 1372.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srl in Genome Data Viewer
    Location:
    10q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11540365..11584506)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (11033976..11078103)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (11240135..11284325)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transcription factor AP-4 Neighboring gene uncharacterized LOC120095030 Neighboring gene uncharacterized LOC134480651 Neighboring gene uncharacterized LOC134480754 Neighboring gene uncharacterized LOC120095031

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice. Zhao X, et al. Physiol Genomics, 2005 Sep 21. PMID 15998745
    2. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to muscle activity involved in regulation of muscle adaptation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within store-operated calcium entry ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sarcalumenin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371633.1 → NP_001358562.1  sarcalumenin isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      FQ224657, JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6G9C9, F1LWG8
      Related
      ENSRNOP00000039064.5, ENSRNOT00000048687.8
      Conserved Domains (4) summary
      cd09913
      Location:526 → 767
      EHD; Eps15 homology domain (EHD), C-terminal domain
      PRK07764
      Location:76 → 309
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      TIGR00927
      Location:271 → 483
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam16880
      Location:490 → 521
      EHD_N; N-terminal EH-domain containing protein

    2. NM_001371781.1 → NP_001358710.1  sarcalumenin isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      FQ224657, JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A0R8, A6K4S8
      Conserved Domains (2) summary
      cd09913
      Location:95 → 336
      EHD; Eps15 homology domain (EHD), C-terminal domain
      pfam16880
      Location:59 → 90
      EHD_N; N-terminal EH-domain containing protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      11540365..11584506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268901.1 → XP_063124971.1  sarcalumenin isoform X2

      Related
      ENSRNOP00000086189.2, ENSRNOT00000111240.2

    2. XM_063268900.1 → XP_063124970.1  sarcalumenin isoform X1

      UniProtKB/TrEMBL
      A0A8I6G9C9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106979.2: Suppressed sequence

      Description
      NM_001106979.2: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from mouse, laboratory: Srl (GeneID:106393).
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.