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    Eml1 EMAP like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362783, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eml1provided by RGD
    Official Full Name
    EMAP like 1provided by RGD
    Primary source
    RGD:1306374
    See related
    EnsemblRapid:ENSRNOG00000043143 AllianceGenome:RGD:1306374
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in brain development; mitotic spindle organization; and neuroblast proliferation. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and microtubule cytoskeleton. Predicted to colocalize with mitotic spindle. Human ortholog(s) of this gene implicated in subcortical band heterotopia. Orthologous to human EML1 (EMAP like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 234.9), Heart (RPKM 166.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Eml1 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (133048271..133221642)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (127283968..127457246)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (132367342..132450488)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene HHIP-like 1 Neighboring gene cytochrome P450, family 46, subfamily a, polypeptide 1 Neighboring gene uncharacterized LOC120103619 Neighboring gene uncharacterized LOC120103620 Neighboring gene uncharacterized LOC134479476 Neighboring gene Enah/Vasp-like Neighboring gene uncharacterized LOC102555052 Neighboring gene microRNA 342 Neighboring gene delta(4)-desaturase, sphingolipid 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC114510

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuroblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle midzone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle midzone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitotic spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    echinoderm microtubule-associated protein-like 1
    Names
    EMAP-1
    echinoderm microtubule associated protein like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025741.2NP_001020912.1  echinoderm microtubule-associated protein-like 1 isoform 5

      See identical proteins and their annotated locations for NP_001020912.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6ASI8
      Related
      ENSRNOP00000067418.4, ENSRNOT00000071733.4
      Conserved Domains (4) summary
      COG2319
      Location:371782
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:153226
      HELP; HELP motif
      sd00039
      Location:342384
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:233621
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001399709.1NP_001386638.1  echinoderm microtubule-associated protein-like 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6ASI8, A0A8I6AVR0
      Related
      ENSRNOP00000096898.1, ENSRNOT00000118546.2
    3. NM_001399710.1NP_001386639.1  echinoderm microtubule-associated protein-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6ASI8
      Related
      ENSRNOP00000097362.2, ENSRNOT00000108825.2
    4. NM_001399711.1NP_001386640.1  echinoderm microtubule-associated protein-like 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q4V8C3
      UniProtKB/TrEMBL
      A0A8I6ASI8
      Related
      ENSRNOP00000090244.2, ENSRNOT00000114172.2
    5. NM_001399712.1NP_001386641.1  echinoderm microtubule-associated protein-like 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6ASI8

    RNA

    1. NR_174190.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
    2. NR_174191.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      133048271..133221642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112547.2XP_038968475.1  echinoderm microtubule-associated protein-like 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A157, A0A8I6ASI8
      Related
      ENSRNOP00000085896.1, ENSRNOT00000107380.2
      Conserved Domains (4) summary
      sd00039
      Location:377419
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:188261
      HELP; HELP motif
      cl29593
      Location:268656
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl41737
      Location:1966
      TD_EMAP-like; trimerization domain of the echinoderm microtubule-associated protein-like family
    2. XM_039112551.2XP_038968479.1  echinoderm microtubule-associated protein-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ASI8
      Conserved Domains (4) summary
      sd00039
      Location:359401
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:170243
      HELP; HELP motif
      cl29593
      Location:250638
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl41737
      Location:148
      TD_EMAP-like; trimerization domain of the echinoderm microtubule-associated protein-like family
    3. XM_063262135.1XP_063118205.1  echinoderm microtubule-associated protein-like 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ASI8
    4. XM_039112546.2XP_038968474.1  echinoderm microtubule-associated protein-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AD94, A0A8I6ASI8
      Conserved Domains (4) summary
      sd00039
      Location:390432
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:201274
      HELP; HELP motif
      cd21947
      Location:2279
      TD_EMAP1; trimerization domain of echinoderm microtubule-associated protein-like 1
      cl29593
      Location:281669
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_039112550.2XP_038968478.1  echinoderm microtubule-associated protein-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ASI8
      Conserved Domains (4) summary
      sd00039
      Location:359401
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:170243
      HELP; HELP motif
      cl29593
      Location:250638
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl41737
      Location:148
      TD_EMAP-like; trimerization domain of the echinoderm microtubule-associated protein-like family
    6. XM_039112552.2XP_038968480.1  echinoderm microtubule-associated protein-like 1 isoform X5

      UniProtKB/TrEMBL
      A6KBG3
      Conserved Domains (3) summary
      sd00039
      Location:251293
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:62135
      HELP; HELP motif
      cl29593
      Location:142530
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    7. XM_039112553.2XP_038968481.1  echinoderm microtubule-associated protein-like 1 isoform X6

      UniProtKB/TrEMBL
      A6KBG3
      Conserved Domains (3) summary
      sd00039
      Location:234276
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:45118
      HELP; HELP motif
      cl29593
      Location:125513
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...