Map3k20 mitogen-activated protein kinase kinase kinase 20 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Map3k20provided by RGD
Official Full Name: mitogen-activated protein kinase kinase kinase 20provided by RGD
Primary source: RGD:1561394
See related: EnsemblRapid:ENSRNOG00000001515 AllianceGenome:RGD:1561394
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zak; MLTK; RGD1561394
Summary: Predicted to enable several functions, including ATP binding activity; JUN kinase kinase kinase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including cellular response to radiation; intracellular signal transduction; and regulation of cellular response to stress. Predicted to act upstream of with a positive effect on pyroptotic inflammatory response. Predicted to act upstream of or within cytoskeleton organization. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 261.3), Heart (RPKM 159.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q23

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (77538146..77697540)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (57130539..57289943)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (58965025..59120507)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of ZAK and/or the ZAK downstream events such as JNK and p38 phosphorylation, c-Jun, and GATA-4 nuclear translocation in cardiac hypertrophy.
Title: ZAK induces cardiomyocyte hypertrophy and brain natriuretic peptide expression via p38/JNK signaling and GATA4/c-Jun transcriptional factor activation.
ZAK activity inhibition may be a good strategy to prevent the cardiac fibrosis progression.
Title: ZAK induces MMP-2 activity via JNK/p38 signals and reduces MMP-9 activity by increasing TIMP-1/2 expression in H9c2 cardiomyoblast cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134323 (e-PCR)
- UniSTS:217605

BG374587 (e-PCR)
- UniSTS:249687

BE097452 (e-PCR)
- UniSTS:244668

RH80553 (e-PCR)
- UniSTS:88774

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables JUN kinase kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables JUN kinase kinase kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables MAP kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase kinase kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables small ribosomal subunit rRNA binding	ISO Inferred from Sequence Orthology more info
enables small ribosomal subunit rRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables stalled ribosome sensor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of GCN2-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of GCN2-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-B	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to gamma radiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in limb development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress-activated protein kinase signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic DNA damage checkpoint	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of programmed cell death	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect pyroptotic inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in stress-activated protein kinase signaling cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitogen-activated protein kinase kinase kinase 20

Names: mitogen-activated protein kinase kinase kinase MLT; sterile alpha motif and leucine zipper containing kinase AZK

NP_001385922.1

EC 2.7.11.25

NP_001385923.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398993.1 → NP_001385922.1 mitogen-activated protein kinase kinase kinase 20 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

D4AE17

Related

ENSRNOP00000002068.3, ENSRNOT00000002068.7

Conserved Domains (2) summary

cd09529
Location:338 → 408

SAM_MLTK; SAM domain of MLTK subfamily

cd14060
Location:22 → 263

STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase
NM_001398994.1 → NP_001385923.1 mitogen-activated protein kinase kinase kinase 20 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5Y262, A0A8I6A4W9

Related

ENSRNOP00000077905.1, ENSRNOT00000112816.2

Conserved Domains (1) summary

cd14060
Location:22 → 263

STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase