U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lrig1 leucine-rich repeats and immunoglobulin-like domains 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312574, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Lrig1provided by RGD
    Official Full Name
    leucine-rich repeats and immunoglobulin-like domains 1provided by RGD
    Primary source
    RGD:1306788
    See related
    EnsemblRapid:ENSRNOG00000012952 AllianceGenome:RGD:1306788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human LRIG1 (leucine rich repeats and immunoglobulin like domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 256.3), Muscle (RPKM 152.5) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Lrig1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (128687723..128788219, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (127130899..127230956, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (126615998..126717434, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102171 Neighboring gene proteasome 20S subunit alpha 3, pseudogene 3 Neighboring gene solute carrier family 25 member 26 Neighboring gene uncharacterized LOC134486819 Neighboring gene apolipoprotein O-like 2 Neighboring gene cytochrome c oxidase subunit 6C, pseudogene 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Lrig1 is a cell-intrinsic modulator of hippocampal dendrite complexity and BDNF signaling. Alsina FC, et al. EMBO Rep, 2016 Apr. PMID 26935556, Free PMC Article
    2. In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear. Del Rio T, et al. PLoS Genet, 2013. PMID 24086156, Free PMC Article
    3. Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. DiTommaso T, et al. PLoS Genet, 2014 Oct. PMID 25340873, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within hair cycle process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within innervation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within otolith morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    leucine-rich repeats and immunoglobulin-like domains protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427801.1 → NP_001414730.1  leucine-rich repeats and immunoglobulin-like domains protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IBE2, M0RB60
      Related
      ENSRNOP00000066785.3, ENSRNOT00000072624.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      128687723..128788219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286082.1 → XP_063142152.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X1

    2. XM_039108763.2 → XP_038964691.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

      Conserved Domains (5) summary
      pfam01463
      Location:8 → 32
      LRRCT; Leucine rich repeat C-terminal domain
      pfam07679
      Location:235 → 322
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:36 → 123
      Ig_3; Immunoglobulin domain
      cd00096
      Location:243 → 246
      Ig; Ig strand A' [structural motif]
      cd05763
      Location:142 → 232
      IgI_LRIG1-like; Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools