Fancd2 FA complementation group D2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fancd2provided by RGD
Official Full Name: FA complementation group D2provided by RGD
Primary source: RGD:1303172
See related: EnsemblRapid:ENSRNOG00000061085 AllianceGenome:RGD:1303172
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA polymerase binding activity. Predicted to be involved in several processes, including meiosis I; mitotic intra-S DNA damage checkpoint signaling; and response to gamma radiation. Predicted to act upstream of or within several processes, including neuronal stem cell population maintenance; regulation of CD40 signaling pathway; and regulation of regulatory T cell differentiation. Predicted to be located in cytosol; nuclear body; and nucleolus. Predicted to be part of DNA repair complex. Predicted to be active in condensed chromosome and nucleus. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group D2; and breast cancer. Orthologous to human FANCD2 (FA complementation group D2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 79.2), Spleen (RPKM 60.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (148234633..148299035)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (146679014..146743422)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (145489869..145551479)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH143207 (e-PCR)
- UniSTS:232454

RH130630 (e-PCR)
- UniSTS:213914

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA polymerase binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA polymerase binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in brain morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair involved in meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamete generation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gamete generation	ISO Inferred from Sequence Orthology more info
involved_in homologous chromosome pairing at meiosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in homologous chromosome pairing at meiosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homologous chromosome pairing at meiosis	ISO Inferred from Sequence Orthology more info
involved_in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic intra-S DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuronal stem cell population maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuronal stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in regulation of CD40 signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of CD40 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of regulatory T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in response to gamma radiation	IEA Inferred from Electronic Annotation more info
involved_in response to gamma radiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of DNA repair complex	IEA Inferred from Electronic Annotation more info
part_of DNA repair complex	ISO Inferred from Sequence Orthology more info
is_active_in condensed chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed chromosome	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Fanconi anemia group D2 protein homolog

Names: Fanconi anemia D2 protein; Fanconi anemia, complementation group D2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001719.2 → NP_001001719.1 Fanconi anemia group D2 protein homolog

See identical proteins and their annotated locations for NP_001001719.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q6IV68

UniProtKB/TrEMBL

A0A8I5XW04, A6IBS9

Conserved Domains (1) summary

pfam14631
Location:38 → 1420

FancD2; Fanconi anaemia protein FancD2 nuclease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

148234633..148299035

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286087.1 → XP_063142157.1 Fanconi anemia group D2 protein homolog isoform X2

UniProtKB/Swiss-Prot

Q6IV68

Related

ENSRNOP00000111154.1, ENSRNOT00000135892.1
XM_039107635.2 → XP_038963563.1 Fanconi anemia group D2 protein homolog isoform X1

UniProtKB/Swiss-Prot

Q6IV68

UniProtKB/TrEMBL

A0A8I5XW04, A6IBS9

Related

ENSRNOP00000077310.1, ENSRNOT00000113277.2

Conserved Domains (1) summary

pfam14631
Location:38 → 1420

FancD2; Fanconi anaemia protein FancD2 nuclease
XM_039107636.2 → XP_038963564.1 Fanconi anemia group D2 protein homolog isoform X1

UniProtKB/Swiss-Prot

Q6IV68

UniProtKB/TrEMBL

A0A8I5XW04, A6IBS9

Conserved Domains (1) summary

pfam14631
Location:38 → 1420

FancD2; Fanconi anaemia protein FancD2 nuclease
XM_039107637.2 → XP_038963565.1 Fanconi anemia group D2 protein homolog isoform X3

Conserved Domains (1) summary

cl17018
Location:1 → 863

FANC; Fanconi anemia ID complex proteins FANCI and FANCD2