U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lrrn4 leucine rich repeat neuronal 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311443, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Lrrn4provided by RGD
    Official Full Name
    leucine rich repeat neuronal 4provided by RGD
    Primary source
    RGD:1305256
    See related
    EnsemblRapid:ENSRNOG00000032989 AllianceGenome:RGD:1305256
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305256
    Summary
    Predicted to be involved in long-term memory. Predicted to act upstream of or within visual learning. Predicted to be active in plasma membrane. Orthologous to human LRRN4 (leucine rich repeat neuronal 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 57.1), Adrenal (RPKM 47.5) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Lrrn4 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (140592303..140603986, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (120138093..120150877, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (125521879..125547685, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene cardiolipin synthase 1 Neighboring gene FERM domain containing kindlin 1 Neighboring gene zinc finger and SCAN domain containing 5B, pseudogene 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory. Bando T, et al. Mol Cell Biol, 2005 May. PMID 15870286, Free PMC Article
    2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in long-term memory IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within long-term memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    leucine-rich repeat neuronal protein 4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430451.1 → NP_001417380.1  leucine-rich repeat neuronal protein 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      F1LTX4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      140592303..140603986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_230550.11 → XP_230550.4  leucine-rich repeat neuronal protein 4

      Related
      ENSRNOP00000048191.4, ENSRNOT00000040802.7
      Conserved Domains (5) summary
      cd00063
      Location:580 → 661
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00116
      Location:163 → 296
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:305 → 317
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:64 → 83
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:177 → 238
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools