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    Cbfa2t3 CBFA2/RUNX1 partner transcriptional co-repressor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361431, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cbfa2t3provided by RGD
    Official Full Name
    CBFA2/RUNX1 partner transcriptional co-repressor 3provided by RGD
    Primary source
    RGD:1310547
    See related
    EnsemblRapid:ENSRNOG00000014723 AllianceGenome:RGD:1310547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of DNA-templated transcription; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of generation of precursor metabolites and energy. Predicted to act upstream of or within granulocyte differentiation and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human CBFA2T3 (CBFA2/RUNX1 partner transcriptional co-repressor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 43.9), Spleen (RPKM 43.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cbfa2t3 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (67584319..67658533, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50679897..50750028, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55438409..55510652, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 2L Neighboring gene PABPN1 like Neighboring gene uncharacterized LOC120098526 Neighboring gene uncharacterized LOC120098493

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration. Kumar P, et al. PLoS One, 2013. PMID 23840896, Free PMC Article
    2. AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation. Ibañez V, et al. Cancer Res, 2004 Jul 1. PMID 15231665
    3. Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1. Kumar P, et al. PLoS One, 2015. PMID 25974097, Free PMC Article
    4. Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors. Cai Y, et al. Biochem Biophys Res Commun, 2009 Dec 11. PMID 19799863, Free PMC Article
    5. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. Barrett CW, et al. PLoS One, 2012. PMID 23251453, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein CBFA2T3
    Names
    CBFA2/RUNX1 translocation partner 3
    core-binding factor, runt domain, alpha subunit 2
    core-binding factor, runt domain, alpha subunit 2; translocated to, 3
    translocated to, 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108453.1 → NP_001101923.1  protein CBFA2T3

      See identical proteins and their annotated locations for NP_001101923.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A0A0G2JVC6, A6IZT7, D4A303
      Related
      ENSRNOP00000019820.4, ENSRNOT00000019820.8
      Conserved Domains (4) summary
      pfam01753
      Location:532 → 568
      zf-MYND; MYND finger
      pfam07531
      Location:147 → 233
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:355 → 421
      NHR2; NHR2 domain like
      cl23750
      Location:460 → 529
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      67584319..67658533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255770.5 → XP_006255832.1  protein CBFA2T3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JVC6
      Conserved Domains (4) summary
      pfam01753
      Location:506 → 542
      zf-MYND; MYND finger
      pfam07531
      Location:121 → 207
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:329 → 395
      NHR2; NHR2 domain like
      cl23750
      Location:434 → 503
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    2. XM_063278155.1 → XP_063134225.1  protein CBFA2T3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JVC6

    3. XM_063278154.1 → XP_063134224.1  protein CBFA2T3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JVC6, A0A8I6AK03

    4. XM_063278153.1 → XP_063134223.1  protein CBFA2T3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JVC6, A0A8I6AK03
      Related
      ENSRNOP00000111221.1, ENSRNOT00000121193.1

    5. XM_006255772.5 → XP_006255834.1  protein CBFA2T3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JVC6
      Conserved Domains (4) summary
      COG2811
      Location:426 → 492
      NtpH; Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]
      pfam08788
      Location:321 → 387
      NHR2; NHR2 domain like
      pfam01753
      Location:498 → 534
      zf-MYND; MYND finger
      pfam07531
      Location:113 → 201
      TAFH; NHR1 homology to TAF

    6. XM_039097877.2 → XP_038953805.1  protein CBFA2T3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JVC6
      Conserved Domains (4) summary
      COG2811
      Location:359 → 425
      NtpH; Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]
      pfam08788
      Location:254 → 320
      NHR2; NHR2 domain like
      pfam01753
      Location:431 → 467
      zf-MYND; MYND finger
      pfam07531
      Location:46 → 134
      TAFH; NHR1 homology to TAF
    Nucleotide Protein Strain
    Heading Accession and Version

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