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    Zxdc ZXD family zinc finger C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zxdcprovided by RGD
    Official Full Name
    ZXD family zinc finger Cprovided by RGD
    Primary source
    RGD:1561296
    See related
    EnsemblRapid:ENSRNOG00000025818 AllianceGenome:RGD:1561296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561296
    Summary
    Predicted to enable C2H2 zinc finger domain binding activity; LRR domain binding activity; and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZXDC (ZXD family zinc finger C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 85.9), Lung (RPKM 70.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zxdc in Genome Data Viewer
    Location:
    4q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (124439560..124471694)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (122882389..122914486)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (122282119..122314251)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 13 Neighboring gene urocanate hydratase 1 Neighboring gene uncharacterized LOC134486812 Neighboring gene cilia and flagella associated protein 100 Neighboring gene KLF transcription factor 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription. Al-Kandari W, et al. Mol Immunol, 2007 Jan. PMID 16600381, Free PMC Article
    2. The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription. Al-Kandari W, et al. J Mol Biol, 2007 Jun 22. PMID 17493635, Free PMC Article
    3. Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain. Jambunathan S, et al. Biol Chem, 2007 Sep. PMID 17696781
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables LRR domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ZXD family zinc finger C; zinc finger protein ZXDC

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431781.1 → NP_001418710.1  ZXD family zinc finger C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5ZSE5, D3ZYP0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      124439560..124471694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002729395.7 → XP_002729441.4  zinc finger protein ZXDC

      Related
      ENSRNOP00000081159.2, ENSRNOT00000116840.2
      Conserved Domains (4) summary
      COG5048
      Location:414 → 692
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:356 → 375
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:398 → 424
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:263 → 340
      zf-C2H2_8; C2H2-type zinc ribbon
    Nucleotide Protein Strain
    Heading Accession and Version

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