Sesn3 sestrin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sesn3provided by RGD
Official Full Name: sestrin 3provided by RGD
Primary source: RGD:1309470
See related: EnsemblRapid:ENSRNOG00000008173 AllianceGenome:RGD:1309470
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Predicted to be involved in several processes, including TORC2 signaling; cellular response to L-leucine; and regulation of signal transduction. Predicted to act upstream of or within glucose homeostasis; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and response to insulin. Predicted to be located in cytoplasm. Predicted to be part of GATOR2 complex and TORC2 complex. Orthologous to human SESN3 (sestrin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 392.0), Thymus (RPKM 305.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (19415307..19470943)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (11133822..11189436)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (12823060..12878749)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sestrin 3 promotes oxidative stress primarily in neurons following epileptic seizures in rats.
Title: Sestrin 3 promotes oxidative stress primarily in neurons following epileptic seizures in rats.
In skeletal muscle Sestrin1 expression is higher than Sestrin3, whereas Sestrin2 expression is markedly lower. Sestrin1 has the highest affinity for leucine and Sestrin3 has the lowest affinity. Overall, the results presented herein are consistent with a model in which leucine-induced activation of mTORC1 in skeletal muscle in vivo occurs primarily through release of Sestrin1 from GATOR2.
Title: Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle.
Results suggest that Sesn3 is a target gene for rno-miR-155. Moreover, the rno-miR-155 antagonist may induce the expression of Sesn3, and then indirectly decrease the damage of oxidative stress to protect the brain from epileptogenesis-associated impairments.
Title: Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.

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General gene information

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Markers

BE118742 (e-PCR)
- UniSTS:248876

BF396297 (e-PCR)
- UniSTS:245723

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-leucine binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on peroxide as acceptor	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in TORC2 signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to L-leucine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leucine starvation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of response to reactive oxygen species	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of GATOR2 complex	ISO Inferred from Sequence Orthology more info
part_of TORC2 complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sestrin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.