Ahcyl1 adenosylhomocysteinase-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ahcyl1provided by RGD
Official Full Name: adenosylhomocysteinase-like 1provided by RGD
Primary source: RGD:1309768
See related: EnsemblRapid:ENSRNOG00000018569 AllianceGenome:RGD:1309768
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IRBIT
Summary: Predicted to enable enzyme regulator activity and identical protein binding activity. Predicted to be involved in several processes, including S-adenosylmethionine cycle; angiotensin-activated signaling pathway; and mitochondrion-endoplasmic reticulum membrane tethering. Predicted to act upstream of or within several processes, including protein export from nucleus; regulation of mRNA 3'-end processing; and regulation of monoatomic ion transport. Located in apical plasma membrane and cytoplasm. Orthologous to human AHCYL1 (adenosylhomocysteinase like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 226.7), Kidney (RPKM 181.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (197982335..198016770, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (195294149..195328586, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (210438884..210474350, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1.
Title: RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1.
IRBIT forms signaling complexes with PIPKIalpha and NBCe1-B, whose activity is regulated by PI(4,5)P2.
Title: IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Iα and IIα through Conserved Catalytic Aspartate Residues.
The present study documents that IRBIT is expressed in Leydig and Sertoli cells.
Title: The IP3 R Binding Protein Released With Inositol 1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and Spermatozoa.
IRBIT is critically involved in mediating activation of NHE3 by ANG II via a Ca(2+)/calmodulin-dependent protein kinases II-dependent pathway.
Title: Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124459 (e-PCR)
- UniSTS:161281

AI176401 (e-PCR)
- UniSTS:250225

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
NOT enables adenosylhomocysteinase activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables adenosylhomocysteinase activity	ISO Inferred from Sequence Orthology more info
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables enzyme regulator activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiotensin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiotensin-activated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial fluid transport	IEA Inferred from Electronic Annotation more info
involved_in epithelial fluid transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion-endoplasmic reticulum membrane tethering	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion-endoplasmic reticulum membrane tethering	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion-endoplasmic reticulum membrane tethering	ISS Inferred from Sequence or Structural Similarity more info
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sodium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA 3'-end processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic anion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of monoatomic anion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	IEA Inferred from Electronic Annotation more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: S-adenosylhomocysteine hydrolase-like protein 1

Names: IP3R-binding protein released with inositol 1,4,5-trisphosphate; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase-like 1; adenosylhomocysteinase 2; adoHcyase 2; putative adenosylhomocysteinase 2

NP_001102031.1

EC 3.13.2.1

XP_006233228.1

EC 3.13.2.1

XP_008759627.2

EC 3.13.2.1

XP_038958635.1

EC 3.13.2.1

XP_063138248.1

EC 3.13.2.1

XP_063138249.1

EC 3.13.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108561.1 → NP_001102031.1 S-adenosylhomocysteine hydrolase-like protein 1

See identical proteins and their annotated locations for NP_001102031.1

Status: PROVISIONAL

Source sequence(s)

CH473952

UniProtKB/TrEMBL

A0A140TAI8, A0A8I5ZSX3

Related

ENSRNOP00000059145.1, ENSRNOT00000066501.5

Conserved Domains (2) summary

smart00996
Location:59 → 442

AdoHcyase; S-adenosyl-L-homocysteine hydrolase

PRK05476
Location:57 → 442

PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

197982335..198016770 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761405.4 → XP_008759627.2 S-adenosylhomocysteine hydrolase-like protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I5ZSX3, A0A8L2UQN5

Related

ENSRNOP00000072856.2, ENSRNOT00000079993.3

Conserved Domains (1) summary

smart00996
Location:106 → 529

AdoHcyase; S-adenosyl-L-homocysteine hydrolase
XM_039102707.2 → XP_038958635.1 S-adenosylhomocysteine hydrolase-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZSX3

Related

ENSRNOP00000082029.2, ENSRNOT00000098324.2

Conserved Domains (1) summary

smart00996
Location:106 → 529

AdoHcyase; S-adenosyl-L-homocysteine hydrolase
XM_006233166.5 → XP_006233228.1 S-adenosylhomocysteine hydrolase-like protein 1 isoform X3

See identical proteins and their annotated locations for XP_006233228.1

UniProtKB/Swiss-Prot

B5DFN2, D4A5X8

UniProtKB/TrEMBL

A0A8I5ZSX3

Conserved Domains (1) summary

smart00996
Location:59 → 482

AdoHcyase; S-adenosyl-L-homocysteine hydrolase
XM_063282178.1 → XP_063138248.1 S-adenosylhomocysteine hydrolase-like protein 1 isoform X4

UniProtKB/TrEMBL

A0A8I6A7K9
XM_063282179.1 → XP_063138249.1 S-adenosylhomocysteine hydrolase-like protein 1 isoform X5

Related

ENSRNOP00000104291.1, ENSRNOT00000158869.1