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    Nop56 NOP56 ribonucleoprotein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362214, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nop56provided by RGD
    Official Full Name
    NOP56 ribonucleoproteinprovided by RGD
    Primary source
    RGD:1308892
    See related
    EnsemblRapid:ENSRNOG00000007128 AllianceGenome:RGD:1308892
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nol5a
    Summary
    Predicted to enable histone methyltransferase binding activity and snoRNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be located in fibrillar center. Predicted to be part of box C/D methylation guide snoRNP complex; pre-snoRNP complex; and small-subunit processome. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 36. Orthologous to human NOP56 (NOP56 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 288.8), Spleen (RPKM 269.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nop56 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (137926187..137934971)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117476963..117481847)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (122803726..122808564)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptides B and B1 Neighboring gene small nucleolar RNA U3 Neighboring gene transmembrane channel-like 2 Neighboring gene small nucleolar RNA SNORA51 Neighboring gene small nucleolar RNA SNORD56 Neighboring gene small nucleolar RNA, C/D box 110 Neighboring gene small nucleolar RNA, C/D box 86 Neighboring gene small nucleolar RNA, C/D box 57 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta Neighboring gene ribosomal protein L31-like 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC116301

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables histone methyltransferase binding  
    enables snoRNA binding  
    enables snoRNA binding  
    Component Evidence Code Pubs
    part_of box C/D methylation guide snoRNP complex  
    located_in fibrillar center  
    located_in fibrillar center  
    part_of pre-snoRNP complex  
    part_of small-subunit processome  
    part_of small-subunit processome  
    part_of sno(s)RNA-containing ribonucleoprotein complex  

    General protein information

    Preferred Names
    nucleolar protein 56
    Names
    NOP56 ribonucleoprotein homolog
    nucleolar protein 5A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025732.1NP_001020903.1  nucleolar protein 56

      See identical proteins and their annotated locations for NP_001020903.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099149
      UniProtKB/TrEMBL
      F7FCF9, Q4KLK7, Q5RJN5
      Related
      ENSRNOP00000009563.4, ENSRNOT00000009564.7
      Conserved Domains (3) summary
      smart00931
      Location:168219
      NOSIC; NOSIC (NUC001) domain
      COG1498
      Location:48416
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam08156
      Location:570
      NOP5NT; NOP5NT (NUC127) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      137926187..137934971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284165.1XP_063140235.1  nucleolar protein 56 isoform X1

    RNA

    1. XR_352612.5 RNA Sequence

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