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    Fat1 FAT atypical cadherin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83720, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fat1provided by RGD
    Official Full Name
    FAT atypical cadherin 1provided by RGD
    Primary source
    RGD:621254
    See related
    EnsemblRapid:ENSRNOG00000030954 AllianceGenome:RGD:621254
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fat; Fath
    Summary
    Predicted to enable calcium ion binding activity. Involved in cellular response to angiotensin and positive regulation of vascular associated smooth muscle cell migration. Located in cytosol and plasma membrane. Human ortholog(s) of this gene implicated in colorectal cancer; esophagus squamous cell carcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and oral squamous cell carcinoma. Orthologous to human FAT1 (FAT atypical cadherin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 354.6), Lung (RPKM 285.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fat1 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (53909759..54029175, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (47177253..47296261, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (50372150..50501716, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS26-like Neighboring gene melatonin receptor 1A Neighboring gene aldolase, fructose-bisphosphate A, pseudogene 1 Neighboring gene uncharacterized LOC108348398

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Planar Cell Polarity Protein Fat1 in Sertoli Cell Function. Bu T, et al. Endocrinology, 2024 Apr 29. PMID 38553880
    2. Comprehensive Genomic Profiling Identifies Novel Genetic Predictors of Response to Anti-PD-(L)1 Therapies in Non-Small Cell Lung Cancer. Fang W, et al. Clin Cancer Res, 2019 Aug 15. PMID 31085721
    3. [FAT1 inhibits cell proliferation of esophageal squamous cell carcinoma through regulating the expression of CDK4/CDK6/CCND1 complex]. Hu XL, et al. Zhonghua Zhong Liu Za Zhi, 2018 Jan 23. PMID 29365412
    4. Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities. Su SC, et al. Theranostics, 2017. PMID 28435450, Free PMC Article
    5. Expression of the rat homologue of the Drosophila fat tumour suppressor gene. Ponassi M, et al. Mech Dev, 1999 Feb. PMID 10072790

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Planar Cell Polarity Protein Fat1 in Sertoli Cell Function.
      Title: The Planar Cell Polarity Protein Fat1 in Sertoli Cell Function.
    2. Fat1 and Atrs 1,2 act in concert after vascular injury but show further that distinct Atr isoforms have disparate effects on VSMC directional migration.
      Title: Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells.
    3. FAT1(WT) is up-regulated in migration, induces cellular process formation when overexpressed, and is necessary for efficient wound healing
      Title: Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells.
    4. Fat1 may control smooth muscle cell functions central to vascular remodeling by facilitating migration and limiting proliferation.
      Title: The Fat1 cadherin integrates vascular smooth muscle cell growth and migration signals.
    5. Fat1 may be a fundamental component of intercellular junctions of podocytes, and may be involved in the initial step of cell contacts of podocytes
      Title: Role of Fat1 in cell-cell contact formation of podocytes in puromycin aminonucleoside nephrosis and neonatal kidney.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in camera-type eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to angiotensin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in epithelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment or maintenance of epithelial cell apical/basal polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lens development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular associated smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protocadherin Fat 1
    Names
    FAT tumor suppressor homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031819.2 → NP_114007.1  protocadherin Fat 1 precursor

      See identical proteins and their annotated locations for NP_114007.1

      Status: PROVISIONAL

      Source sequence(s)
      AF100960
      UniProtKB/TrEMBL
      A6JPS5, G3V9W9, Q9WU10
      Related
      ENSRNOP00000073466.1, ENSRNOT00000081023.3
      Conserved Domains (5) summary
      cd11304
      Location:3340 → 3437
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:3855 → 3986
      LamG; Laminin G domain
      cd00054
      Location:4128 → 4164
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:4094 → 4124
      EGF; EGF-like domain
      cl09101
      Location:278 → 357
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      53909759..54029175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275780.1 → XP_063131850.1  protocadherin Fat 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K5L1

    2. XM_063275784.1 → XP_063131854.1  protocadherin Fat 1 isoform X7

      UniProtKB/TrEMBL
      A6JPS5, G3V9W9

    3. XM_039094866.2 → XP_038950794.1  protocadherin Fat 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K5L1
      Conserved Domains (4) summary
      cd11304
      Location:3363 → 3460
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:3878 → 4009
      LamG; Laminin G domain
      cd00054
      Location:4114 → 4150
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl29226
      Location:278 → 357
      Cadherin; Cadherin domain

    4. XM_063275783.1 → XP_063131853.1  protocadherin Fat 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K5L1

    5. XM_017600262.3 → XP_017455751.1  protocadherin Fat 1 isoform X4

      UniProtKB/TrEMBL
      A6JPS5, G3V9W9
      Related
      ENSRNOP00000061869.2, ENSRNOT00000067486.3

    6. XM_017600259.3 → XP_017455748.1  protocadherin Fat 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K5L1
      Conserved Domains (5) summary
      cd11304
      Location:3363 → 3460
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00282
      Location:3878 → 4009
      LamG; Laminin G domain
      cd00054
      Location:4151 → 4187
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:4117 → 4147
      EGF; EGF-like domain
      cl29226
      Location:278 → 357
      Cadherin; Cadherin domain

    7. XM_063275777.1 → XP_063131847.1  protocadherin Fat 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5L1, A0A8I6AEP7
      Related
      ENSRNOP00000096269.2, ENSRNOT00000112869.2

    8. XM_063275778.1 → XP_063131848.1  protocadherin Fat 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5L1, A0A8I6AEP7

    9. XM_063275781.1 → XP_063131851.1  protocadherin Fat 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K5L1

    10. XM_063275782.1 → XP_063131852.1  protocadherin Fat 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K5L1

    11. XM_063275779.1 → XP_063131849.1  protocadherin Fat 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5L1, A0A8I6AEP7

    12. XM_063275785.1 → XP_063131855.1  protocadherin Fat 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AQL3
      Related
      ENSRNOP00000111050.1, ENSRNOT00000159710.1

    RNA

    1. XR_005494675.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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