As3mt arsenite methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: As3mtprovided by RGD
Official Full Name: arsenite methyltransferaseprovided by RGD
Primary source: RGD:621325
See related: EnsemblRapid:ENSRNOG00000020081 AllianceGenome:RGD:621325
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyt19
Summary: Enables arsenite methyltransferase activity. Involved in arsonoacetate metabolic process and toxin metabolic process. Acts upstream of or within response to arsenic-containing substance. Located in cytosol. Orthologous to human AS3MT (arsenite methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 936.0), Adrenal (RPKM 211.8) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (255536879..255569245)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (245595939..245628921)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (266482787..266514570)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In rat AS3MT, Cys156 located in a well-defined cavity structure may be situated to participate in the binding of substrates which contain A(III).
Title: Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype.
Enzyme catalyzing the conversion of inorganic arsenic to volatile arsenicals.
Title: Glutathione modulates recombinant rat arsenic (+3 oxidation state) methyltransferase-catalyzed formation of trimethylarsine oxide and trimethylarsine.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables arsenite methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arsenite methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables arsenite methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables arsenite methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein methyltransferase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in arsonoacetate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arsonoacetate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in arsonoacetate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in arsonoacetate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in methylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
involved_in toxin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in toxin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in toxin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in toxin metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: arsenite methyltransferase

Names: S-adenosyl-L-methionine:arsenic(III) methyltransferase; S-adenosylmethionine:arsenic (III) methyltransferase; arsenic (+3 oxidation state) methyltransferase; methylarsonite methyltransferase; methyltransferase Cyt19

NP_543166.2

EC 2.1.1.137

XP_038938593.2

EC 2.1.1.137

XP_038938624.1

EC 2.1.1.137

XP_063127220.1

EC 2.1.1.137

XP_063127291.1

EC 2.1.1.137

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080890.2 → NP_543166.2 arsenite methyltransferase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q8VHT6

UniProtKB/TrEMBL

A6JHN7, G3V8P2

Related

ENSRNOP00000027223.5, ENSRNOT00000027223.8

Conserved Domains (1) summary

PRK11873
Location:60 → 265

arsM; arsenite methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

255536879..255569245

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082696.2 → XP_038938624.1 arsenite methyltransferase isoform X3

UniProtKB/Swiss-Prot

Q8VHT6

Conserved Domains (1) summary

PRK11873
Location:60 → 206

arsM; arsenite methyltransferase
XM_063271150.1 → XP_063127220.1 arsenite methyltransferase isoform X2

UniProtKB/Swiss-Prot

Q8VHT6
XM_039082665.2 → XP_038938593.2 arsenite methyltransferase isoform X1
XM_063271221.1 → XP_063127291.1 arsenite methyltransferase isoform X4

UniProtKB/TrEMBL

A6JHN8