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    Slc2a8 solute carrier family 2 member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85256, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc2a8provided by RGD
    Official Full Name
    solute carrier family 2 member 8provided by RGD
    Primary source
    RGD:620611
    See related
    EnsemblRapid:ENSRNOG00000022274 AllianceGenome:RGD:620611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Glut8
    Summary
    Enables dehydroascorbic acid transmembrane transporter activity. Involved in dehydroascorbic acid transport and male meiosis I. Located in synaptic vesicle. Orthologous to human SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 115.4), Brain (RPKM 76.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Slc2a8 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36672589..36682206, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (16274918..16284536, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (12020227..12029920, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene niban apoptosis regulator 2 Neighboring gene leucine rich repeat and sterile alpha motif containing 1 Neighboring gene small nucleolar RNA, H/ACA box 65 Neighboring gene uncharacterized LOC120101525 Neighboring gene ribosomal protein L12 Neighboring gene GTPase activating Rap/RanGAP domain-like 3 Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene angiopoietin-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport  
    involved_in D-glucose transmembrane transport  
    acts_upstream_of_or_within D-glucose transmembrane transport  
    involved_in D-glucose transmembrane transport  
    involved_in D-glucose transmembrane transport  
    involved_in dehydroascorbic acid transport PubMed 
    involved_in dehydroascorbic acid transport  
    involved_in dehydroascorbic acid transport  
    involved_in fructose transmembrane transport  
    involved_in fructose transmembrane transport  
    involved_in fructose transmembrane transport  
    involved_in insulin receptor signaling pathway  
    acts_upstream_of_or_within insulin receptor signaling pathway  
    involved_in male meiosis I PubMed 
    involved_in response to hypoxia  
    acts_upstream_of_or_within response to hypoxia  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane  
    is_active_in membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in synaptic vesicle PubMed 

    General protein information

    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 8
    Names
    GLUT-8
    glucose transporter type 8
    glucose transporter type X1
    solute carrier family 2, (facilitated glucose transporter) member 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429585.1NP_001416514.1  solute carrier family 2, facilitated glucose transporter member 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JUA0
    2. NM_001429586.1NP_001416515.1  solute carrier family 2, facilitated glucose transporter member 8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    3. NM_053494.3NP_445946.2  solute carrier family 2, facilitated glucose transporter member 8 isoform 1

      See identical proteins and their annotated locations for NP_445946.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q9JJZ1, Q9JMA6
      UniProtKB/TrEMBL
      A6JUA0
      Related
      ENSRNOP00000022326.4, ENSRNOT00000022327.5
      Conserved Domains (1) summary
      cl28910
      Location:27470
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      36672589..36682206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761779.4XP_008760001.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X1

      Conserved Domains (2) summary
      cd06174
      Location:30402
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:29417
      Sugar_tr; Sugar (and other) transporter
    2. XM_063284736.1XP_063140806.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X2

    3. XM_039105998.2XP_038961926.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:27290
      MFS; Major Facilitator Superfamily
    4. XM_063284738.1XP_063140808.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X5

    5. XM_039105999.2XP_038961927.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:27290
      MFS; Major Facilitator Superfamily
    6. XM_063284739.1XP_063140809.1  solute carrier family 2, facilitated glucose transporter member 8 isoform X5

    RNA

    1. XR_010064707.1 RNA Sequence

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