U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Ahr aryl hydrocarbon receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25690, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ahrprovided by RGD
    Official Full Name
    aryl hydrocarbon receptorprovided by RGD
    Primary source
    RGD:2074
    See related
    EnsemblRapid:ENSRNOG00000004342 AllianceGenome:RGD:2074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including arachidonate omega-hydroxylase activity; nuclear receptor activity; and toxic substance binding activity. Involved in several processes, including cellular response to steroid hormone stimulus; negative regulation of cell population proliferation; and regulation of macromolecule biosynthetic process. Located in cytoplasm and nucleus. Used to study hypertension; hypertrophic cardiomyopathy; pulmonary hypertension; and transient cerebral ischemia. Biomarker of hypertension and traumatic brain injury. Human ortholog(s) of this gene implicated in retinitis pigmentosa 85. Orthologous to human AHR (aryl hydrocarbon receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 311.4), Liver (RPKM 218.9) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ahr in Genome Data Viewer
    Location:
    6q16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (57961423..57998901, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (52234089..52271568, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (54963990..55001806, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 13 Neighboring gene heat shock protein 90 beta family member 1, pseudogene 2 Neighboring gene uncharacterized LOC102554773 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 39
    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables E-box binding  
    enables E-box binding  
    enables Hsp90 protein binding  
    enables Hsp90 protein binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables TBP-class protein binding  
    enables TBP-class protein binding  
    enables TFIID-class transcription factor complex binding  
    enables TFIID-class transcription factor complex binding  
    enables arachidonate omega-hydroxylase activity PubMed 
    enables aryl hydrocarbon receptor binding  
    enables cis-regulatory region sequence-specific DNA binding  
    enables cis-regulatory region sequence-specific DNA binding  
    enables identical protein binding  
    enables nuclear receptor activity PubMed 
    enables nuclear receptor activity  
    contributes_to nuclear receptor activity  
    enables nuclear receptor activity  
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein-folding chaperone binding  
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding PubMed 
    enables sequence-specific double-stranded DNA binding PubMed 
    enables sequence-specific double-stranded DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables toxic substance binding PubMed 
    enables transcription cis-regulatory region binding  
    enables transcription cis-regulatory region binding  
    enables transcription coactivator binding  
    enables transcription coactivator binding  
    Items 1 - 25 of 39
    Items 1 - 25 of 106
    Process Evidence Code Pubs
    involved_in B cell homeostasis  
    involved_in T cell homeostasis  
    involved_in aflatoxin metabolic process PubMed 
    involved_in apoptotic process PubMed 
    involved_in blood circulation  
    involved_in blood vessel development  
    involved_in blood vessel morphogenesis  
    involved_in blood vessel remodeling  
    involved_in branching involved in blood vessel morphogenesis  
    involved_in camera-type eye development  
    involved_in cardiac left ventricle morphogenesis  
    involved_in cell morphogenesis  
    involved_in cellular response to 2,3,7,8-tetrachlorodibenzodioxine PubMed 
    involved_in cellular response to 2,3,7,8-tetrachlorodibenzodioxine  
    involved_in cellular response to 2,3,7,8-tetrachlorodibenzodioxine  
    involved_in cellular response to 3-methylcholanthrene  
    involved_in cellular response to cAMP  
    involved_in cellular response to cAMP  
    involved_in cellular response to dexamethasone stimulus PubMed 
    involved_in cellular response to forskolin  
    involved_in cellular response to forskolin  
    involved_in cellular response to glucocorticoid stimulus PubMed 
    involved_in cellular response to molecule of bacterial origin  
    involved_in cellular response to molecule of bacterial origin  
    involved_in cellular response to toxic substance PubMed 
    involved_in circadian regulation of gene expression  
    involved_in circadian regulation of gene expression  
    involved_in circadian rhythm PubMed 
    involved_in circumferential growth involved in left ventricle morphogenesis  
    involved_in conditioned taste aversion PubMed 
    involved_in contact inhibition PubMed 
    involved_in estrogen receptor signaling pathway PubMed 
    involved_in female pregnancy PubMed 
    acts_upstream_of_or_within gland development  
    involved_in glomerulus morphogenesis  
    involved_in immune system process  
    involved_in intracellular receptor signaling pathway  
    involved_in kidney morphogenesis  
    involved_in liver development  
    involved_in lymphocyte homeostasis  
    involved_in mammary duct terminal end bud growth PubMed 
    involved_in negative regulation of DNA biosynthetic process PubMed 
    involved_in negative regulation of DNA biosynthetic process PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of T cell mediated immune response to tumor cell  
    involved_in negative regulation of T cell mediated immune response to tumor cell  
    involved_in negative regulation of T cell mediated immune response to tumor cell  
    involved_in negative regulation of alkaline phosphatase activity PubMed 
    involved_in negative regulation of calcium ion transmembrane transport PubMed 
    involved_in negative regulation of epithelial cell proliferation PubMed 
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of inflammatory response  
    involved_in negative regulation of osteoblast differentiation PubMed 
    involved_in negative regulation of osteoblast proliferation PubMed 
    involved_in negative regulation of systemic arterial blood pressure  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of vasoconstriction  
    involved_in nitric oxide metabolic process PubMed 
    involved_in omega-hydroxylase P450 pathway PubMed 
    involved_in ovarian follicle development PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of RNA polymerase II transcription preinitiation complex assembly  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of cell size  
    involved_in positive regulation of growth rate  
    involved_in positive regulation of mating-type specific transcription, DNA-templated PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in post-embryonic hemopoiesis  
    acts_upstream_of_or_within prostate gland development  
    involved_in protein localization to nucleus PubMed 
    involved_in reactive oxygen species biosynthetic process PubMed 
    involved_in regulation of B cell proliferation  
    involved_in regulation of B cell proliferation  
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of adaptive immune response  
    involved_in regulation of adaptive immune response  
    involved_in regulation of cell cycle PubMed 
    involved_in regulation of cytokine production PubMed 
    involved_in regulation of eating behavior PubMed 
    involved_in regulation of gene expression  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within reproductive structure development  
    involved_in response to arsenic-containing substance PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to toxic substance  
    involved_in response to toxic substance PubMed 
    involved_in response to toxic substance  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in response to xenobiotic stimulus  
    involved_in rhythmic process  
    involved_in spleen development  
    involved_in tissue remodeling PubMed 
    involved_in transcription by RNA polymerase II PubMed 
    involved_in transcription by RNA polymerase II  
    involved_in vasculature development  
    involved_in xenobiotic metabolic process  
    Items 1 - 25 of 106
    Component Evidence Code Pubs
    part_of aryl hydrocarbon receptor complex  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    part_of nuclear aryl hydrocarbon receptor complex  
    part_of nuclear aryl hydrocarbon receptor complex  
    part_of nuclear aryl hydrocarbon receptor complex  
    is_active_in nucleus  
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in nucleus  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    aryl hydrocarbon receptor
    Names
    ah receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308254.1NP_001295183.1  aryl hydrocarbon receptor isoform 2

      See identical proteins and their annotated locations for NP_001295183.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end of the coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HB98, A8YPR0, G3V6M2
      Related
      ENSRNOP00000006618.6, ENSRNOT00000006618.9
      Conserved Domains (5) summary
      smart00353
      Location:3677
      HLH; helix loop helix domain
      smart00091
      Location:111177
      PAS; PAS domain
      cd00130
      Location:280384
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:111181
      PAS; PAS fold
      pfam08447
      Location:295380
      PAS_3; PAS fold
    2. NM_001308255.1NP_001295184.1  aryl hydrocarbon receptor isoform 3

      See identical proteins and their annotated locations for NP_001295184.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction in the 3' end of the coding sequence compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HB96, A8YPQ9
      Conserved Domains (5) summary
      smart00353
      Location:3677
      HLH; helix loop helix domain
      smart00091
      Location:111177
      PAS; PAS domain
      cd00130
      Location:280384
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:111181
      PAS; PAS fold
      pfam08447
      Location:295380
      PAS_3; PAS fold
    3. NM_013149.3NP_037281.3  aryl hydrocarbon receptor isoform 1

      See identical proteins and their annotated locations for NP_037281.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      O88930, O89105, P41738
      UniProtKB/TrEMBL
      A6HB97, A8YPR4
      Related
      ENSRNOP00000111098.1, ENSRNOT00000136687.1
      Conserved Domains (5) summary
      smart00091
      Location:111177
      PAS; PAS domain
      cd00083
      Location:3677
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:280384
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:111181
      PAS; PAS fold
      pfam08447
      Location:295380
      PAS_3; PAS fold

    RNA

    1. NR_131775.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      JAXUCZ010000006
    2. NR_131776.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      57961423..57998901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.