U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Adcy10 adenylate cyclase 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59320, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adcy10provided by RGD
    Official Full Name
    adenylate cyclase 10provided by RGD
    Primary source
    RGD:708450
    See related
    EnsemblRapid:ENSRNOG00000053410 AllianceGenome:RGD:708450
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sac
    Summary
    Enables ATPase binding activity; adenylate cyclase activity; and manganese ion binding activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of apoptotic process; and positive regulation of phosphate metabolic process. Located in several cellular components, including astrocyte end-foot; central region of growth cone; and neuronal cell body. Orthologous to human ADCY10 (adenylate cyclase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 147.9), Liver (RPKM 19.0) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adcy10 in Genome Data Viewer
    Location:
    13q23
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80280595..80366939)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (77747752..77833952)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83701952..83787010)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 161 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene uncharacterized LOC134481587 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene uncharacterized LOC134481588 Neighboring gene myelin protein zero-like 1 Neighboring gene transfer RNA proline (anticodon AGG) 14

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATPase binding PubMed 
    enables adenylate cyclase activity  
    enables adenylate cyclase activity PubMed 
    enables adenylate cyclase activity  
    enables bicarbonate binding  
    enables bicarbonate binding  
    enables magnesium ion binding  
    enables manganese ion binding PubMed 
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    involved_in cAMP biosynthetic process PubMed 
    involved_in cAMP biosynthetic process PubMed 
    involved_in cAMP biosynthetic process  
    involved_in epithelial cilium movement involved in extracellular fluid movement  
    involved_in epithelial cilium movement involved in extracellular fluid movement  
    involved_in glucose catabolic process PubMed 
    involved_in intracellular signal transduction  
    involved_in mitochondrial ATP transmembrane transport PubMed 
    involved_in negative regulation of cardiac muscle cell contraction PubMed 
    involved_in negative regulation of mitochondrial membrane potential PubMed 
    involved_in negative regulation of reactive oxygen species biosynthetic process PubMed 
    involved_in neuron projection extension PubMed 
    involved_in neuron projection maintenance PubMed 
    involved_in neuron projection retraction PubMed 
    involved_in positive regulation of ATP biosynthetic process PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of axon extension PubMed 
    involved_in positive regulation of cAMP-dependent protein kinase activity PubMed 
    involved_in positive regulation of cardiac muscle cell apoptotic process PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy PubMed 
    involved_in positive regulation of glycogen catabolic process PubMed 
    involved_in positive regulation of intrinsic apoptotic signaling pathway PubMed 
    involved_in positive regulation of mitochondrial depolarization PubMed 
    involved_in positive regulation of ossification PubMed 
    involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway PubMed 
    involved_in positive regulation of peptidyl-threonine phosphorylation PubMed 
    involved_in positive regulation of protein targeting to mitochondrion PubMed 
    involved_in positive regulation of reactive oxygen species biosynthetic process PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell apoptotic process PubMed 
    involved_in regulation of membrane repolarization PubMed 
    involved_in regulation of mitophagy PubMed 
    involved_in spermatid development PubMed 
    Items 1 - 25 of 32
    Items 1 - 20 of 25
    Component Evidence Code Pubs
    located_in apical part of cell PubMed 
    located_in apical plasma membrane  
    located_in astrocyte end-foot PubMed 
    located_in axon PubMed 
    located_in basal part of cell PubMed 
    located_in central region of growth cone PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytosol PubMed 
    located_in dendrite PubMed 
    located_in extracellular region  
    located_in growth cone PubMed 
    located_in membrane  
    located_in microtubule cytoskeleton  
    located_in microtubule cytoskeleton  
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in motile cilium  
    located_in motile cilium  
    located_in neuronal cell body PubMed 
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    Items 1 - 20 of 25

    General protein information

    Preferred Names
    adenylate cyclase type 10
    Names
    adenylate cyclase 10 (soluble)
    germ cell soluble adenylyl cyclase
    soluble adenylyl cyclase
    testicular soluble adenylyl cyclase
    NP_067716.1
    XP_008767899.1
    XP_008767900.1
    XP_038946977.1
    XP_038946978.1
    XP_038946979.1
    XP_038946980.1
    XP_063128634.1
    XP_063128635.1
    XP_063128636.1
    XP_063128637.1
    XP_063128638.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021684.1NP_067716.1  adenylate cyclase type 10

      See identical proteins and their annotated locations for NP_067716.1

      Status: PROVISIONAL

      Source sequence(s)
      AF081941
      UniProtKB/Swiss-Prot
      Q9Z286
      Related
      ENSRNOP00000072356.1, ENSRNOT00000082677.3
      Conserved Domains (3) summary
      cd07302
      Location:40214
      CHD; cyclase homology domain
      COG2114
      Location:42197
      AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
      pfam13191
      Location:485670
      AAA_16; AAA ATPase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      80280595..80366939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272565.1XP_063128635.1  adenylate cyclase type 10 isoform X2

    2. XM_063272564.1XP_063128634.1  adenylate cyclase type 10 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z286
    3. XM_008769677.4XP_008767899.1  adenylate cyclase type 10 isoform X1

      See identical proteins and their annotated locations for XP_008767899.1

      UniProtKB/Swiss-Prot
      Q9Z286
      Conserved Domains (3) summary
      cd07302
      Location:40214
      CHD; cyclase homology domain
      COG2114
      Location:42197
      AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
      pfam13191
      Location:485670
      AAA_16; AAA ATPase domain
    4. XM_008769678.4XP_008767900.1  adenylate cyclase type 10 isoform X1

      See identical proteins and their annotated locations for XP_008767900.1

      UniProtKB/Swiss-Prot
      Q9Z286
      Conserved Domains (3) summary
      cd07302
      Location:40214
      CHD; cyclase homology domain
      COG2114
      Location:42197
      AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
      pfam13191
      Location:485670
      AAA_16; AAA ATPase domain
    5. XM_063272566.1XP_063128636.1  adenylate cyclase type 10 isoform X4

    6. XM_063272567.1XP_063128637.1  adenylate cyclase type 10 isoform X8

    7. XM_039091049.2XP_038946977.1  adenylate cyclase type 10 isoform X3

      Conserved Domains (1) summary
      cd07302
      Location:22162
      CHD; cyclase homology domain
    8. XM_039091050.1XP_038946978.1  adenylate cyclase type 10 isoform X5

    9. XM_039091051.1XP_038946979.1  adenylate cyclase type 10 isoform X6

    10. XM_039091052.1XP_038946980.1  adenylate cyclase type 10 isoform X7

    11. XM_063272568.1XP_063128638.1  adenylate cyclase type 10 isoform X9

      UniProtKB/TrEMBL
      A6IDH3
    External link. Please review our privacy policy.