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    Syt17 synaptotagmin 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192189, updated on 9-Dec-2024

    Summary

    Official Symbol
    Syt17provided by RGD
    Official Full Name
    synaptotagmin 17provided by RGD
    Primary source
    RGD:708576
    See related
    EnsemblRapid:ENSRNOG00000017136 AllianceGenome:RGD:708576
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bk
    Summary
    Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in positive regulation of dendrite extension; regulation of vesicle-mediated transport; and vesicle-mediated transport. Predicted to be located in trans-Golgi network. Predicted to be active in several cellular components, including exocytic vesicle; glutamatergic synapse; and postsynapse. Orthologous to human SYT17 (synaptotagmin 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 51.7), Kidney (RPKM 45.3) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Syt17 in Genome Data Viewer
    Location:
    1q35
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (182129491..182195827, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (172695275..172761906, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (188034614..188101590, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485170 Neighboring gene C-type lectin domain containing 19A Neighboring gene uncharacterized LOC134485171 Neighboring gene ITPRIP like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNARE binding  
    enables calcium ion sensor activity  
    enables calcium-dependent phospholipid binding  
    Component Evidence Code Pubs
    is_active_in exocytic vesicle  
    is_active_in glutamatergic synapse  
    located_in membrane  
    is_active_in plasma membrane  
    is_active_in postsynapse  
    located_in trans-Golgi network  

    General protein information

    Preferred Names
    synaptotagmin-17
    Names
    B/K protein
    brain and kidney protein
    protein B/K
    synaptotagmin XVII
    sytXVII

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138849.2NP_620204.1  synaptotagmin-17

      See identical proteins and their annotated locations for NP_620204.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q62807
      Related
      ENSRNOP00000112301.1, ENSRNOT00000169376.1
      Conserved Domains (2) summary
      cd08390
      Location:186314
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:323457
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      182129491..182195827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588770.3XP_017444259.2  synaptotagmin-17 isoform X3

      UniProtKB/TrEMBL
      A6I8H0
      Related
      ENSRNOP00000100243.1, ENSRNOT00000140655.1
      Conserved Domains (2) summary
      cd08390
      Location:125253
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:262396
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
    2. XM_039092421.2XP_038948349.1  synaptotagmin-17 isoform X2

      UniProtKB/TrEMBL
      A0A0U1RRV6
      Related
      ENSRNOP00000023090.5, ENSRNOT00000023090.6
      Conserved Domains (2) summary
      cd08390
      Location:180308
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:317451
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
    3. XM_063278991.1XP_063135061.1  synaptotagmin-17 isoform X3

      UniProtKB/TrEMBL
      A6I8H0
      Related
      ENSRNOP00000075827.3, ENSRNOT00000092435.3
    4. XM_006230104.2XP_006230166.1  synaptotagmin-17 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9H6
      Related
      ENSRNOP00000105386.1, ENSRNOT00000122794.1
      Conserved Domains (2) summary
      cd08390
      Location:182310
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:319453
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
    5. XM_017588772.2XP_017444261.1  synaptotagmin-17 isoform X3

      UniProtKB/TrEMBL
      A6I8H0
      Conserved Domains (2) summary
      cd08390
      Location:125253
      C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
      cd08410
      Location:262396
      C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
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