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Nrg1 neuregulin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 112400, updated on 9-Dec-2024

Summary

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Official Symbol: Nrg1provided by RGD
Official Full Name: neuregulin 1provided by RGD
Primary source: RGD:621341
See related: EnsemblRapid:ENSRNOG00000010392 AllianceGenome:RGD:621341
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables receptor tyrosine kinase binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; cellular response to L-glutamate; and positive regulation of cell population proliferation. Located in several cellular components, including dendrite; extracellular space; and neuronal cell body. Used to study Alzheimer's disease and sciatic neuropathy. Biomarker of several diseases, including amblyopia; epilepsy (multiple); interstitial cystitis; neuropathy (multiple); and overactive bladder syndrome. Human ortholog(s) of this gene implicated in several diseases, including cannabis dependence; cerebral malaria; cerebrovascular disease (multiple); psychotic disorder (multiple); and substance abuse (multiple). Orthologous to human NRG1 (neuregulin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 31.6), Brain (RPKM 16.8) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Nrg1 in Genome Data Viewer

Location:: 16q12.3

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (65954084..67007484)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (59250658..60304519)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (62969573..64065063)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Changes in Type II NRG-1 Expression during Regeneration Following Autologous Nerve Transplantation in Rats.
Title: Changes in Type II NRG-1 Expression during Regeneration Following Autologous Nerve Transplantation in Rats.
MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPbeta modification in rats.
Title: MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPβ modification in rats.
Neuregulin-1 signaling regulates cytokines and chemokines expression and secretion in granulosa cell.
Title: Neuregulin-1 signaling regulates cytokines and chemokines expression and secretion in granulosa cell.
MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats.
Title: MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats.
Effect of regulation of the NRG1/ErbB4 signaling pathway on the visual cortex synaptic plasticity of amblyopic adult rats.
Title: Effect of regulation of the NRG1/ErbB4 signaling pathway on the visual cortex synaptic plasticity of amblyopic adult rats.
Neuregulin-1 alleviate oxidative stress and mitigate inflammation by suppressing NOX4 and NLRP3/caspase-1 in myocardial ischaemia-reperfusion injury.
Title: Neuregulin-1 alleviate oxidative stress and mitigate inflammation by suppressing NOX4 and NLRP3/caspase-1 in myocardial ischaemia-reperfusion injury.
Jinmaitong ameliorates diabetic peripheral neuropathy in streptozotocin-induced diabetic rats by modulating gut microbiota and neuregulin 1.
Title: Jinmaitong ameliorates diabetic peripheral neuropathy in streptozotocin-induced diabetic rats by modulating gut microbiota and neuregulin 1.
Nrg1/ErbB2 regulates differentiation and apoptosis of neural stem cells in the cochlear nucleus through PI3K/Akt pathway.
Title: Nrg1/ErbB2 regulates differentiation and apoptosis of neural stem cells in the cochlear nucleus through PI3K/Akt pathway.
Fibroblasts Colonizing Nerve Conduits Express High Levels of Soluble Neuregulin1, a Factor Promoting Schwann Cell Dedifferentiation.
Title: Fibroblasts Colonizing Nerve Conduits Express High Levels of Soluble Neuregulin1, a Factor Promoting Schwann Cell Dedifferentiation.
Upregulated neuregulin-1 protects against optic nerve injury by regulating the RhoA/cofilin/F-actin axis.
Title: Upregulated neuregulin-1 protects against optic nerve injury by regulating the RhoA/cofilin/F-actin axis.

Submit: New GeneRIF Correction See all GeneRIFs (113)

General gene information

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Markers

UniSTS:468010 (e-PCR)
- UniSTS:468010

Nrg1 (e-PCR), detects polymorphism
- UniSTS:468010

D16Wox15 (e-PCR)
- UniSTS:519020

D16Wox14 (e-PCR)
- UniSTS:518551

D16Rat109 (e-PCR), detects polymorphism
- UniSTS:226767

D16Rat60 (e-PCR), detects polymorphism
- UniSTS:226794

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ErbB-2 class receptor binding	ISO Inferred from Sequence Orthology more info
enables ErbB-3 class receptor binding	IEA Inferred from Electronic Annotation more info
enables ErbB-3 class receptor binding	ISO Inferred from Sequence Orthology more info
enables ErbB-3 class receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables chemorepellent activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemorepellent activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERBB signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ERBB signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in ERBB2-ERBB3 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERBB2-ERBB3 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ERBB2-ERBB3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ERBB2-ERBB4 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ERBB2-ERBB4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ERBB3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ERBB4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERBB4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ERBB4-ERBB4 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ERBB4-ERBB4 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in Schwann cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Schwann cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase B activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac conduction system development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell apoptotic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell myoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to L-glutamate	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to acetylcholine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to brain-derived neurotrophic factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to ciliary neurotrophic factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to potassium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to serotonin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within chemorepulsion involved in interneuron migration from the subpallium to the cortex	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in endocardial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in endocardial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within glial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glial cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in locomotory behavior	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal response to stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within muscle organ development	ISO Inferred from Sequence Orthology more info
involved_in myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myelination in peripheral nervous system	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of corticosterone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of secretion	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within peripheral nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Schwann cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon regeneration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of striated muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in postsynapse to nucleus signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sequestering of metal ion	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in ventricular trabecula myocardium morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular trabecula myocardium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in basal part of cell	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mossy fiber rosette	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pro-neuregulin-1, membrane-bound isoform

Names: glial growth factor; neuregulin 1 type III beta 3; pro-NRG1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271118.3 → NP_001258047.1 pro-neuregulin-1, membrane-bound isoform isoform 1

See identical proteins and their annotated locations for NP_001258047.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A0G2K3Q3, A6IVV2, Q9ESB1

Related

ENSRNOP00000072731.1, ENSRNOT00000081522.3

Conserved Domains (2) summary

PHA02887
Location:237 → 280

PHA02887; EGF-like protein; Provisional

pfam02158
Location:296 → 688

Neuregulin; Neuregulin family
NM_001271119.3 → NP_001258048.1 pro-neuregulin-1, membrane-bound isoform isoform 2

See identical proteins and their annotated locations for NP_001258048.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two alternate coding exons and contains another alternate coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1, with the two isoforms containing an alternate internal segment.

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A0G2K057, A6IVV1, Q9ESB0

Related

ENSRNOP00000071312.1, ENSRNOT00000082355.3

Conserved Domains (2) summary

PHA02887
Location:237 → 279

PHA02887; EGF-like protein; Provisional

pfam02158
Location:291 → 683

Neuregulin; Neuregulin family
NM_001271120.3 → NP_001258049.1 pro-neuregulin-1, membrane-bound isoform isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate coding exons and contains two other alternate coding exons compared to variant 1. The resulting isoform (3) contains an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A6IVV4, G3V7D6

Related

ENSRNOP00000013991.6, ENSRNOT00000013991.10

Conserved Domains (2) summary

PHA02887
Location:237 → 279

PHA02887; EGF-like protein; Provisional

pfam02158
Location:323 → 479

Neuregulin; Neuregulin family
NM_001271121.3 → NP_001258050.1 pro-neuregulin-1, membrane-bound isoform isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

Q52NV2

Conserved Domains (4) summary

PHA03099
Location:148 → 237

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam00008
Location:156 → 186

EGF; EGF-like domain

cd05895
Location:37 → 129

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam02158
Location:230 → 584

Neuregulin; Neuregulin family
NM_001271122.3 → NP_001258051.1 pro-neuregulin-1, membrane-bound isoform isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and contains an alternate exon compared to variant 1. The resulting isoform (5) has shorter and distinct N- and C-termini compared to isoform 1.

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

D3ZC94, Q52NV1

Related

ENSRNOP00000031467.6, ENSRNOT00000038549.9

Conserved Domains (3) summary

pfam00008
Location:156 → 186

EGF; EGF-like domain

cd05895
Location:37 → 129

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam02158
Location:238 → 394

Neuregulin; Neuregulin family
NM_001271123.1 → NP_001258052.1 pro-neuregulin-1, membrane-bound isoform isoform 6

See identical proteins and their annotated locations for NP_001258052.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) has shorter and distinct N- and C-termini compared to isoform 1.

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A6IVV0

Conserved Domains (2) summary

cd05895
Location:53 → 127

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

smart00410
Location:43 → 129

IG_like; Immunoglobulin like
NM_001271124.1 → NP_001258053.1 pro-neuregulin-1, membrane-bound isoform isoform 7

See identical proteins and their annotated locations for NP_001258053.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence, lacks two alternate coding exons, and contains another alternate coding exon compared to variant 1. The resulting isoform (7) has a shorter and distinct N-terminus, a shorter C-terminus, and contains an alternate internal segment compared to isoform 1.

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A6IVU8, A6IVU9

Conserved Domains (4) summary

cd05895
Location:53 → 127

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

smart00410
Location:43 → 129

IG_like; Immunoglobulin like

pfam00008
Location:190 → 220

EGF; EGF-like domain

pfam02158
Location:235 → 422

Neuregulin; Neuregulin family
NM_001271125.3 → NP_001258054.1 pro-neuregulin-1, membrane-bound isoform isoform 8

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence, lacks an alternate coding exon, and contains two other alternate coding exons compared to variant 1. The resulting isoform (8) contains an alternate internal segment and has shorter and distinct N- and C-termini compared to isoform 1.

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

Q52NV1

Conserved Domains (3) summary

pfam00008
Location:190 → 220

EGF; EGF-like domain

cd05895
Location:37 → 129

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam02158
Location:290 → 446

Neuregulin; Neuregulin family
NM_001271126.3 → NP_001258055.1 pro-neuregulin-1, membrane-bound isoform isoform 9

See identical proteins and their annotated locations for NP_001258055.1

Status: VALIDATED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (9) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A6IVU5, Q52NV3

Related

ENSRNOP00000077747.2, ENSRNOT00000099919.2

Conserved Domains (4) summary

cd05895
Location:53 → 127

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

smart00410
Location:43 → 129

IG_like; Immunoglobulin like

pfam00008
Location:190 → 220

EGF; EGF-like domain

pfam02158
Location:240 → 632

Neuregulin; Neuregulin family
NM_001271127.3 → NP_001258056.1 pro-neuregulin-1, membrane-bound isoform isoform 10 preproprotein

See identical proteins and their annotated locations for NP_001258056.1

Status: VALIDATED

Description

Transcript Variant: This variant (10) differs in the 5' UTR and coding sequence, lacks an alternate coding exon, and contains another alternate coding exon compared to variant 1. The resulting isoform (10) has a shorter and distinct N-terminus and contains an alternate internal segment compared to isoform 1.

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

P43322, P43323, P43324, P43325, P43326, P43327, P43328

UniProtKB/TrEMBL

A6IVU4, G3V7F0

Related

ENSRNOP00000014268.5, ENSRNOT00000014268.10

Conserved Domains (4) summary

cd05895
Location:53 → 127

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

smart00410
Location:43 → 129

IG_like; Immunoglobulin like

pfam00008
Location:190 → 220

EGF; EGF-like domain

pfam02158
Location:258 → 650

Neuregulin; Neuregulin family
NM_001271128.3 → NP_001258057.1 pro-neuregulin-1, membrane-bound isoform isoform 11

See identical proteins and their annotated locations for NP_001258057.1

Status: VALIDATED

Description

Transcript Variant: This variant (11) differs in the 5' UTR and coding sequence, lacks an alternate in-frame exon, and contains an alternate exon compared to variant 1. The resulting isoform (11) has shorter and distinct N- and C-termini and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A6IVU7, A6IVU9

Conserved Domains (4) summary

cd05895
Location:53 → 127

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

smart00410
Location:43 → 129

IG_like; Immunoglobulin like

pfam00008
Location:190 → 220

EGF; EGF-like domain

pfam02158
Location:235 → 423

Neuregulin; Neuregulin family
NM_001271129.4 → NP_001258058.1 pro-neuregulin-1, membrane-bound isoform isoform 12

See identical proteins and their annotated locations for NP_001258058.1

Status: VALIDATED

Description

Transcript Variant: This variant (12) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (12) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A6IVU3, Q52NV3

Conserved Domains (4) summary

cd05895
Location:53 → 127

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

smart00410
Location:43 → 129

IG_like; Immunoglobulin like

pfam00008
Location:190 → 220

EGF; EGF-like domain

pfam02158
Location:235 → 627

Neuregulin; Neuregulin family
NM_001271130.3 → NP_001258059.1 pro-neuregulin-1, membrane-bound isoform isoform 14

Status: VALIDATED

Description

Transcript Variant: This variant (14) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (14) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

Q52NV3

Conserved Domains (3) summary

pfam00008
Location:197 → 227

EGF; EGF-like domain

cd05895
Location:44 → 136

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam02158
Location:279 → 633

Neuregulin; Neuregulin family
NM_031588.4 → NP_113776.2 pro-neuregulin-1, membrane-bound isoform isoform 13

See identical proteins and their annotated locations for NP_113776.2

Status: VALIDATED

Description

Transcript Variant: This variant (13) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (13) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A6IVU6, Q52NV3

Conserved Domains (4) summary

cd05895
Location:53 → 127

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

PHA03099
Location:182 → 271

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

smart00410
Location:43 → 129

IG_like; Immunoglobulin like

pfam02158
Location:232 → 624

Neuregulin; Neuregulin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

65954084..67007484

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274979.1 → XP_063131049.1 pro-neuregulin-1, membrane-bound isoform isoform X5

UniProtKB/TrEMBL

Q52NV1
XM_063274980.1 → XP_063131050.1 pro-neuregulin-1, membrane-bound isoform isoform X6

UniProtKB/TrEMBL

A6IVU9
XM_063274978.1 → XP_063131048.1 pro-neuregulin-1, membrane-bound isoform isoform X2

UniProtKB/TrEMBL

Q52NV2
XM_063274982.1 → XP_063131052.1 pro-neuregulin-1, membrane-bound isoform isoform X8

UniProtKB/TrEMBL

Q9ESB1
XM_017599969.3 → XP_017455458.1 pro-neuregulin-1, membrane-bound isoform isoform X1

UniProtKB/TrEMBL

A0A8I5ZKD3, A6IVV3, Q9ESB1

Conserved Domains (2) summary

PHA03099
Location:238 → 327

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam02158
Location:288 → 680

Neuregulin; Neuregulin family
XM_017599971.3 → XP_017455460.1 pro-neuregulin-1, membrane-bound isoform isoform X3

UniProtKB/TrEMBL

A6IVV4
XM_039094096.2 → XP_038950024.1 pro-neuregulin-1, membrane-bound isoform isoform X4

UniProtKB/TrEMBL

A6IVV4

Conserved Domains (2) summary

pfam02158
Location:320 → 476

Neuregulin; Neuregulin family

NF033760
Location:127 → 223

gliding_GltG; adventurous gliding motility protein GltG
XM_063274981.1 → XP_063131051.1 pro-neuregulin-1, membrane-bound isoform isoform X7