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    Ube2o ubiquitin-conjugating enzyme E2O [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303689, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ube2oprovided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2Oprovided by RGD
    Primary source
    RGD:1310297
    See related
    EnsemblRapid:ENSRNOG00000011007 AllianceGenome:RGD:1310297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310297
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Predicted to be located in cytoplasm and nuclear body. Orthologous to human UBE2O (ubiquitin conjugating enzyme E2 O). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 394.1), Brain (RPKM 140.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ube2o in Genome Data Viewer
    Location:
    10q32.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102264418..102311578, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101765572..101812736, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105505721..105553167, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 1 Neighboring gene sphk1a antisense transcript Neighboring gene sphingosine kinase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L14, pseudogene 1 Neighboring gene aralkylamine N-acetyltransferase

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin-protein transferase activity  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    (E3-independent) E2 ubiquitin-conjugating enzyme
    NP_001414251.1
    XP_017453235.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427322.1NP_001414251.1  (E3-independent) E2 ubiquitin-conjugating enzyme

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A0W6, A6HKX6
      Related
      ENSRNOP00000083906.1, ENSRNOT00000110885.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      102264418..102311578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597746.3XP_017453235.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1

      UniProtKB/TrEMBL
      A6HKX6
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