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    Naga alpha-N-acetylgalactosaminidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315165, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nagaprovided by RGD
    Official Full Name
    alpha-N-acetylgalactosaminidaseprovided by RGD
    Primary source
    RGD:1306025
    See related
    EnsemblRapid:ENSRNOG00000008064 AllianceGenome:RGD:1306025
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alpha-N-acetylgalactosaminidase activity; alpha-galactosidase activity; and protein homodimerization activity. Predicted to be involved in several processes, including glycolipid catabolic process; glycoside catabolic process; and oligosaccharide metabolic process. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to human NAGA (alpha-N-acetylgalactosaminidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 157.7), Lung (RPKM 124.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Naga in Genome Data Viewer
    Location:
    7q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115726438..115735494, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113846358..113855430, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123563047..123572074, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351520 Neighboring gene septin 3 Neighboring gene WBP2 N-terminal like Neighboring gene uncharacterized LOC134479948 Neighboring gene PH domain containing endocytic trafficking adaptor 2 Neighboring gene single-pass membrane protein with aspartate-rich tail 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-N-acetylgalactosaminidase activity  
    enables alpha-N-acetylgalactosaminidase activity  
    enables alpha-N-acetylgalactosaminidase activity  
    enables alpha-galactosidase activity  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in carbohydrate catabolic process  
    involved_in carbohydrate catabolic process  
    involved_in carbohydrate catabolic process  
    involved_in carbohydrate metabolic process  
    involved_in glycolipid catabolic process  
    involved_in glycolipid catabolic process  
    involved_in glycolipid catabolic process  
    involved_in glycoside catabolic process  
    involved_in oligosaccharide metabolic process  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in lysosome  
    located_in membrane  

    General protein information

    Preferred Names
    alpha-N-acetylgalactosaminidase
    Names
    N-acetyl galactosaminidase, alpha
    alpha-galactosidase B
    NP_001012120.1
    XP_006242149.1
    XP_006242150.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012120.1NP_001012120.1  alpha-N-acetylgalactosaminidase precursor

      See identical proteins and their annotated locations for NP_001012120.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082084
      UniProtKB/Swiss-Prot
      Q66H12
      UniProtKB/TrEMBL
      A0A8I6B4W8, A6HT60
      Related
      ENSRNOP00000096846.2, ENSRNOT00000097900.2
      Conserved Domains (1) summary
      cl07893
      Location:25394
      AmyAc_family; Alpha amylase catalytic domain family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      115726438..115735494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242088.5XP_006242150.1  alpha-N-acetylgalactosaminidase isoform X1

      See identical proteins and their annotated locations for XP_006242150.1

      UniProtKB/Swiss-Prot
      Q66H12
      UniProtKB/TrEMBL
      A0A8I6B4W8, A6HT60
      Conserved Domains (1) summary
      cl07893
      Location:25394
      AmyAc_family; Alpha amylase catalytic domain family
    2. XM_006242087.5XP_006242149.1  alpha-N-acetylgalactosaminidase isoform X1

      See identical proteins and their annotated locations for XP_006242149.1

      UniProtKB/Swiss-Prot
      Q66H12
      UniProtKB/TrEMBL
      A0A8I6B4W8, A6HT60
      Related
      ENSRNOP00000060590.2, ENSRNOT00000068020.4
      Conserved Domains (1) summary
      cl07893
      Location:25394
      AmyAc_family; Alpha amylase catalytic domain family
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