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    Neurod2 neuronal differentiation 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54276, updated on 9-Dec-2024

    Summary

    Official Symbol
    Neurod2provided by RGD
    Official Full Name
    neuronal differentiation 2provided by RGD
    Primary source
    RGD:3166
    See related
    EnsemblRapid:ENSRNOG00000028417 AllianceGenome:RGD:3166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including nervous system development; regulation of DNA-templated transcription; and regulation of synapse maturation. Predicted to act upstream of or within associative learning; behavioral fear response; and neuron development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 72. Orthologous to human NEUROD2 (neuronal differentiation 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Neurod2 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83820092..83824277, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83323801..83327986, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86280865..86282681, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 1 Neighboring gene cyclin-dependent kinase 12 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1B Neighboring gene StAR-related lipid transfer domain containing 3

    Genomic regions, transcripts, and products

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables E-box binding  
    enables E-box binding  
    enables E-box binding  
    enables E-box binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables sequence-specific double-stranded DNA binding  
    Items 1 - 25 of 40
    Process Evidence Code Pubs
    involved_in associative learning  
    acts_upstream_of_or_within associative learning  
    involved_in axon development  
    involved_in behavioral fear response  
    acts_upstream_of_or_within behavioral fear response  
    involved_in cellular response to calcium ion  
    involved_in cellular response to calcium ion  
    involved_in cellular response to calcium ion  
    involved_in cellular response to electrical stimulus  
    involved_in cellular response to electrical stimulus  
    involved_in cellular response to electrical stimulus  
    involved_in cerebellar cortex development  
    involved_in cerebellar cortex development  
    involved_in cerebellar cortex development  
    involved_in negative regulation of synapse maturation  
    involved_in negative regulation of synapse maturation  
    involved_in negative regulation of synapse maturation  
    involved_in neuron development  
    acts_upstream_of_or_within neuron development  
    involved_in positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of calcium-mediated signaling  
    involved_in positive regulation of calcium-mediated signaling  
    involved_in positive regulation of calcium-mediated signaling  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of synapse maturation  
    involved_in positive regulation of synapse maturation  
    involved_in positive regulation of synapse maturation  
    involved_in positive regulation of synaptic plasticity  
    involved_in positive regulation of synaptic plasticity  
    involved_in positive regulation of synaptic plasticity  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in sensory organ development  
    Items 1 - 25 of 40
    Component Evidence Code Pubs
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    neurogenic differentiation factor 2
    Names
    brain bHLH protein KW8
    neurogenic differentiation 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019326.2NP_062199.2  neurogenic differentiation factor 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q63689
      UniProtKB/TrEMBL
      A0A8I6A9H9
      Related
      ENSRNOP00000089812.1, ENSRNOT00000038833.5
      Conserved Domains (2) summary
      cd19720
      Location:88180
      bHLH_TS_NeuroD2; basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) and similar proteins
      pfam12533
      Location:180310
      Neuro_bHLH; Neuronal helix-loop-helix transcription factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83820092..83824277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086671.1XP_038942599.1  neurogenic differentiation factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q63689
      UniProtKB/TrEMBL
      A0A8I6A9H9
      Related
      ENSRNOP00000111755.1, ENSRNOT00000123149.1
      Conserved Domains (2) summary
      cd19720
      Location:88180
      bHLH_TS_NeuroD2; basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) and similar proteins
      pfam12533
      Location:180310
      Neuro_bHLH; Neuronal helix-loop-helix transcription factor
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