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    Serbp1 Serpine1 mRNA binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246303, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serbp1provided by RGD
    Official Full Name
    Serpine1 mRNA binding protein 1provided by RGD
    Primary source
    RGD:619907
    See related
    EnsemblRapid:ENSRNOG00000005890 AllianceGenome:RGD:619907
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rda288; Pairbp1; Pai-Rbp1
    Summary
    Predicted to enable several functions, including SUMO binding activity; mRNA 3'-UTR binding activity; and translation elongation factor binding activity. Involved in regulation of apoptotic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human SERBP1 (SERPINE1 mRNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 1203.8), Thymus (RPKM 1137.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Serbp1 in Genome Data Viewer
    Location:
    4q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (97731200..97748438)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (96401587..96421816)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (98027563..98044717)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 12 Neighboring gene uncharacterized LOC100912188 Neighboring gene growth arrest and DNA-damage-inducible, alpha Neighboring gene uncharacterized LOC120102291 Neighboring gene interleukin 12 receptor subunit beta 2 Neighboring gene interleukin 23 receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC94773

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA binding  
    enables SUMO binding  
    enables SUMO binding  
    enables SUMO binding  
    enables mRNA 3'-UTR binding  
    enables mRNA 3'-UTR binding  
    enables mRNA 3'-UTR binding  
    enables mRNA 3'-UTR binding  
    enables ribosome binding  
    enables ribosome binding  
    enables ribosome binding  
    enables translation elongation factor binding  
    enables translation elongation factor binding  
    enables translation repressor activity  
    enables translation repressor activity  
    enables translation repressor activity  
    Process Evidence Code Pubs
    involved_in PML body organization  
    involved_in PML body organization  
    involved_in PML body organization  
    involved_in negative regulation of translation  
    involved_in negative regulation of translation  
    involved_in regulation of apoptotic process PubMed 
    involved_in regulation of translation  
    involved_in ribosome hibernation  
    involved_in ribosome hibernation  
    involved_in ribosome hibernation  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    SERPINE1 mRNA-binding protein 1
    Names
    PAI-1 mRNA-binding protein
    PAI1 RNA-binding protein 1
    RNA binding protein RDA288
    hypothetical RNA binding protein RDA288
    plasminogen activator inhibitor 1 RNA-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145086.1NP_659554.1  SERPINE1 mRNA-binding protein 1

      See identical proteins and their annotated locations for NP_659554.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079337
      UniProtKB/TrEMBL
      A0A8I6G6Q3, A6KF48
      Conserved Domains (2) summary
      pfam04774
      Location:189297
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5152
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      97731200..97748438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236616.4XP_006236678.1  SERPINE1 mRNA-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006236678.1

      UniProtKB/Swiss-Prot
      Q6AXS5, Q8VHU3
      UniProtKB/TrEMBL
      A0A8I6G6Q3, A6KF47
      Related
      ENSRNOP00000086511.1, ENSRNOT00000106917.2
      Conserved Domains (2) summary
      pfam04774
      Location:189312
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5152
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
    2. XM_006236617.4XP_006236679.1  SERPINE1 mRNA-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G6Q3
      Conserved Domains (2) summary
      pfam04774
      Location:189306
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5152
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
    3. XM_006236618.4XP_006236680.1  SERPINE1 mRNA-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G6Q3
      Conserved Domains (2) summary
      pfam04774
      Location:189291
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5152
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
    4. XM_039107049.2XP_038962977.1  SERPINE1 mRNA-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8L2Q518
      Related
      ENSRNOP00000009503.7, ENSRNOT00000009503.9
      Conserved Domains (2) summary
      pfam04774
      Location:189267
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5152
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
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