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    Ttc5 tetratricopeptide repeat domain 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305837, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ttc5provided by RGD
    Official Full Name
    tetratricopeptide repeat domain 5provided by RGD
    Primary source
    RGD:1311284
    See related
    EnsemblRapid:ENSRNOG00000008850 AllianceGenome:RGD:1311284
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity; chromatin binding activity; and ribosome binding activity. Predicted to be involved in DNA damage response; cellular response to starvation; and positive regulation of mRNA catabolic process. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including cytosol; mitochondrion; and nucleoplasm. Orthologous to human TTC5 (tetratricopeptide repeat domain 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 165.0), Brain (RPKM 144.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ttc5 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (26466613..26484269, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (23993046..24010710, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (27698375..27715970, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 11 subfamily H member 23, pseudogene 1 Neighboring gene olfactory receptor family 11 subfamily H member 4 Neighboring gene cyclin B1 interacting protein 1 Neighboring gene small nucleolar RNA SNORD126 Neighboring gene poly (ADP-ribose) polymerase 2 Neighboring gene ribonuclease P RNA component H1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC108914

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables chromatin binding  
    enables ribosome binding  
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in DNA repair  
    involved_in cellular response to starvation  
    involved_in cellular response to starvation  
    involved_in positive regulation of mRNA catabolic process  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in cytosol  
    located_in mitochondrial matrix  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 5
    Names
    TPR repeat protein 5
    protein Strap
    strap
    stress-responsive activator of p300

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013131.1NP_001013149.1  tetratricopeptide repeat protein 5

      See identical proteins and their annotated locations for NP_001013149.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091207
      UniProtKB/Swiss-Prot
      Q5BK48
      UniProtKB/TrEMBL
      A0A8I6GIP6, A6KEA5
      Related
      ENSRNOP00000011741.5, ENSRNOT00000011741.9
      Conserved Domains (3) summary
      COG0457
      Location:47256
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:6897
      TPR; TPR repeat [structural motif]
      pfam16669
      Location:318432
      TTC5_OB; Tetratricopeptide repeat protein 5 OB fold domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      26466613..26484269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274219.1XP_063130289.1  tetratricopeptide repeat protein 5 isoform X1

    2. XM_039093271.2XP_038949199.1  tetratricopeptide repeat protein 5 isoform X2

      Conserved Domains (2) summary
      sd00006
      Location:6897
      TPR; TPR repeat [structural motif]
      NF033920
      Location:67131
      C39_PA2778_fam; PA2778 family cysteine peptidase

    RNA

    1. XR_010057812.1 RNA Sequence

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