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    Spc25 SPC25 component of NDC80 kinetochore complex [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spc25provided by RGD
    Official Full Name
    SPC25 component of NDC80 kinetochore complexprovided by RGD
    Primary source
    RGD:1307811
    See related
    EnsemblRapid:ENSRNOG00000006731 AllianceGenome:RGD:1307811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spbc25; RGD1307811
    Summary
    Predicted to be involved in attachment of spindle microtubules to kinetochore and mitotic spindle organization. Predicted to be located in cytosol and kinetochore. Predicted to be part of Ndc80 complex. Orthologous to human SPC25 (SPC25 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 132.7), Spleen (RPKM 63.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spc25 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (74337872..74396825, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (53930013..53988940, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (55438534..55451961, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ceramide synthase 6 Neighboring gene uncharacterized LOC134486099 Neighboring gene Y box binding protein 1, pseudogene 9 Neighboring gene nitric oxide synthase trafficking Neighboring gene glucose-6-phosphatase catalytic subunit 2 Neighboring gene ATP binding cassette subfamily B member 11 Neighboring gene DNA mismatch repair protein Msh6-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of two novel components of the human NDC80 kinetochore complex. Bharadwaj R, et al. J Biol Chem, 2004 Mar 26. PMID 14699129
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC108932

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ndc80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Ndc80 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore protein Spc25
    Names
    SPC25, NDC80 kinetochore complex component, homolog
    spindle pole body component 25 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009654.1 → NP_001009654.1  kinetochore protein Spc25

      See identical proteins and their annotated locations for NP_001009654.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088213
      UniProtKB/Swiss-Prot
      Q5M856
      UniProtKB/TrEMBL
      A6HLZ8
      Related
      ENSRNOP00000008837.5, ENSRNOT00000008837.7
      Conserved Domains (2) summary
      pfam10186
      Location:28 → 129
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
      pfam08234
      Location:153 → 220
      Spindle_Spc25; Chromosome segregation protein Spc25

    2. NM_001429843.1 → NP_001416772.1  kinetochore protein Spc25

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q5M856
      UniProtKB/TrEMBL
      A6HLZ8

    3. NM_001429844.1 → NP_001416773.1  kinetochore protein Spc25

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q5M856
      UniProtKB/TrEMBL
      A6HLZ8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      74337872..74396825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104490.1 → XP_038960418.1  kinetochore protein Spc25 isoform X2

      Conserved Domains (1) summary
      pfam10186
      Location:28 → 129
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

    2. XM_063283274.1 → XP_063139344.1  kinetochore protein Spc25 isoform X1

    3. XM_039104489.2 → XP_038960417.1  kinetochore protein Spc25 isoform X1

      Conserved Domains (2) summary
      pfam10186
      Location:28 → 129
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
      pfam08234
      Location:153 → 220
      Spindle_Spc25; Chromosome segregation protein Spc25

    4. XM_039104491.2 → XP_038960419.1  kinetochore protein Spc25 isoform X3

      Conserved Domains (1) summary
      pfam10186
      Location:28 → 129
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M856.1 GenPept UniProtKB/Swiss-Prot:Q5M856

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