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    Lrmda leucine rich melanocyte differentiation associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681383, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrmdaprovided by RGD
    Official Full Name
    leucine rich melanocyte differentiation associatedprovided by RGD
    Primary source
    RGD:1596707
    See related
    EnsemblRapid:ENSRNOG00000069198 AllianceGenome:RGD:1596707
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in melanocyte differentiation. Human ortholog(s) of this gene implicated in oculocutaneous albinism type VII. Orthologous to human LRMDA (leucine rich melanocyte differentiation associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 36.0), Spleen (RPKM 25.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrmda in Genome Data Viewer
    Location:
    15p16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (1275139..2334153, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (1223098..2284764, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (1269869..2346246, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693799 Neighboring gene U6 spliceosomal RNA Neighboring gene potassium calcium-activated channel subfamily M alpha 1 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA threonine (anticodon AGU) 13 Neighboring gene transfer RNA proline (anticodon AGG) 44 Neighboring gene zinc finger protein 503

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in c10orf11, a melanocyte-differentiation gene, cause autosomal-recessive albinism. Grønskov K, et al. Am J Hum Genet, 2013 Mar 7. PMID 23395477, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in melanocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in melanocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich melanocyte differentiation-associated protein
    Names
    leucine-rich repeat-containing protein C10orf11 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109441.1 → NP_001102911.1  leucine-rich melanocyte differentiation-associated protein

      See identical proteins and their annotated locations for NP_001102911.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474061
      UniProtKB/TrEMBL
      A0A8I6GL34, A6KKT9
      Related
      ENSRNOP00000094277.2, ENSRNOT00000117097.2
      Conserved Domains (4) summary
      cd00116
      Location:27 → 113
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:34 → 54
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:54 → 93
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:53 → 112
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      1275139..2334153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274633.1 → XP_063130703.1  leucine-rich melanocyte differentiation-associated protein isoform X5

      UniProtKB/TrEMBL
      A0A8I6GL34, A6KKT9

    2. XM_063274632.1 → XP_063130702.1  leucine-rich melanocyte differentiation-associated protein isoform X4

    3. XM_063274635.1 → XP_063130705.1  leucine-rich melanocyte differentiation-associated protein isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZZ54

    4. XM_063274629.1 → XP_063130699.1  leucine-rich melanocyte differentiation-associated protein isoform X1

    5. XM_063274630.1 → XP_063130700.1  leucine-rich melanocyte differentiation-associated protein isoform X2

    6. XM_063274636.1 → XP_063130706.1  leucine-rich melanocyte differentiation-associated protein isoform X8

    7. XM_063274634.1 → XP_063130704.1  leucine-rich melanocyte differentiation-associated protein isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZZ54

    8. XM_063274631.1 → XP_063130701.1  leucine-rich melanocyte differentiation-associated protein isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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