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    Lpar1 lysophosphatidic acid receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116744, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lpar1provided by RGD
    Official Full Name
    lysophosphatidic acid receptor 1provided by RGD
    Primary source
    RGD:620563
    See related
    EnsemblRapid:ENSRNOG00000013656 AllianceGenome:RGD:620563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Edg2
    Summary
    Enables G-protein alpha-subunit binding activity and phospholipid binding activity. Involved in several processes, including cellular response to 1-oleoyl-sn-glycerol 3-phosphate; nervous system development; and regulation of vesicle-mediated transport. Located in dendritic shaft; dendritic spine; and neuronal cell body. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Used to study hepatocellular carcinoma and transient cerebral ischemia. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 71.1), Uterus (RPKM 44.2) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lpar1 in Genome Data Viewer
    Location:
    5q24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (78024139..78147071, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (73229047..73347874, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (75557038..75678067, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546532 Neighboring gene sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Neighboring gene RIKEN cDNA 4930522L14 gene like Neighboring gene muscle associated receptor tyrosine kinase Neighboring gene uncharacterized LOC120103153 Neighboring gene brain expressed, X-linked 1, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC105279

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity PubMed 
    enables G-protein alpha-subunit binding PubMed 
    enables PDZ domain binding  
    enables lysophosphatidic acid binding  
    enables lysophosphatidic acid receptor activity  
    enables lysophosphatidic acid receptor activity  
    enables lysophosphatidic acid receptor activity  
    enables phospholipid binding PubMed 
    Items 1 - 25 of 47
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within bleb assembly  
    involved_in cell chemotaxis  
    involved_in cellular response to 1-oleoyl-sn-glycerol 3-phosphate PubMed 
    involved_in cellular response to oxygen levels PubMed 
    involved_in cerebellum development PubMed 
    involved_in corpus callosum development PubMed 
    involved_in myelination PubMed 
    involved_in negative regulation of cAMP/PKA signal transduction PubMed 
    involved_in negative regulation of cilium assembly  
    involved_in negative regulation of cilium assembly  
    involved_in negative regulation of neuron projection development PubMed 
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of neuron projection development  
    involved_in neurogenesis  
    involved_in neurogenesis PubMed 
    involved_in oligodendrocyte development PubMed 
    involved_in optic nerve development PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    acts_upstream_of_or_within positive regulation of Rho protein signal transduction  
    involved_in positive regulation of Rho protein signal transduction  
    involved_in positive regulation of Rho protein signal transduction  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of dendritic spine development PubMed 
    involved_in positive regulation of smooth muscle cell chemotaxis PubMed 
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of stress fiber assembly  
    involved_in regulation of cell shape  
    involved_in regulation of cell shape  
    involved_in regulation of metabolic process  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of synaptic vesicle cycle PubMed 
    involved_in regulation of synaptic vesicle cycle PubMed 
    involved_in regulation of synaptic vesicle cycle PubMed 
    involved_in regulation of synaptic vesicle cycle PubMed 
    Items 1 - 25 of 47
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    is_active_in GABA-ergic synapse PubMed 
    is_active_in GABA-ergic synapse PubMed 
    located_in cell surface  
    located_in cell surface  
    is_active_in cytoplasm  
    located_in dendritic shaft PubMed 
    located_in dendritic spine PubMed 
    located_in endocytic vesicle  
    located_in endosome  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in neuronal cell body PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic membrane PubMed 
    is_active_in presynaptic membrane PubMed 

    General protein information

    Preferred Names
    lysophosphatidic acid receptor 1
    Names
    LPA receptor 1
    LPA-1
    endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
    lysophosphatidic acid receptor Edg-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053936.4NP_446388.1  lysophosphatidic acid receptor 1

      See identical proteins and their annotated locations for NP_446388.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P61794, Q5FWS2
      UniProtKB/TrEMBL
      A6KDV2
      Related
      ENSRNOP00000043652.2, ENSRNOT00000044348.4
      Conserved Domains (1) summary
      cd15344
      Location:50322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      78024139..78147071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287075.1XP_063143145.1  lysophosphatidic acid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      P61794, Q5FWS2
      UniProtKB/TrEMBL
      A6KDV2
    2. XM_006238195.5XP_006238257.1  lysophosphatidic acid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006238257.1

      UniProtKB/Swiss-Prot
      P61794, Q5FWS2
      UniProtKB/TrEMBL
      A6KDV2
      Conserved Domains (1) summary
      cd15344
      Location:50322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
    3. XM_017593125.3XP_017448614.1  lysophosphatidic acid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      P61794, Q5FWS2
      UniProtKB/TrEMBL
      A6KDV2
      Conserved Domains (1) summary
      cd15344
      Location:50322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
    4. XM_006238201.5XP_006238263.1  lysophosphatidic acid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006238263.1

      UniProtKB/Swiss-Prot
      P61794, Q5FWS2
      UniProtKB/TrEMBL
      A6KDV2
      Conserved Domains (1) summary
      cd15344
      Location:50322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
    5. XM_006238197.5XP_006238259.1  lysophosphatidic acid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006238259.1

      UniProtKB/Swiss-Prot
      P61794, Q5FWS2
      UniProtKB/TrEMBL
      A6KDV2
      Conserved Domains (1) summary
      cd15344
      Location:50322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
    6. XM_063287076.1XP_063143146.1  lysophosphatidic acid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      P61794, Q5FWS2
      UniProtKB/TrEMBL
      A6KDV2
    7. XM_063287077.1XP_063143147.1  lysophosphatidic acid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      P61794, Q5FWS2
      UniProtKB/TrEMBL
      A6KDV2
    8. XM_017593127.3XP_017448616.1  lysophosphatidic acid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      P61794, Q5FWS2
      UniProtKB/TrEMBL
      A6KDV2
      Conserved Domains (1) summary
      cd15344
      Location:50322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
    9. XM_063287078.1XP_063143148.1  lysophosphatidic acid receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      P61794, Q5FWS2
      UniProtKB/TrEMBL
      A6KDV2
    10. XM_006238200.5XP_006238262.1  lysophosphatidic acid receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006238262.1

      UniProtKB/Swiss-Prot
      P61794, Q5FWS2
      UniProtKB/TrEMBL
      A6KDV2
      Conserved Domains (1) summary
      cd15344
      Location:50322
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
    11. XM_017593130.3XP_017448619.1  lysophosphatidic acid receptor 1 isoform X2

      Conserved Domains (1) summary
      cd15344
      Location:32304
      7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
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