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    Dbh dopamine beta-hydroxylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25699, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dbhprovided by RGD
    Official Full Name
    dopamine beta-hydroxylaseprovided by RGD
    Primary source
    RGD:2489
    See related
    EnsemblRapid:ENSRNOG00000006641 AllianceGenome:RGD:2489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DOPBHY
    Summary
    Enables copper ion binding activity and dopamine beta-monooxygenase activity. Involved in several processes, including cellular response to manganese ion; cellular response to nicotine; and norepinephrine biosynthetic process. Located in several cellular components, including axon; dendrite; and neuronal cell body. Biomarker of brain ischemia; depressive disorder; hypertension; and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 642.7) See more
    Orthologs
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    Genomic context

    See Dbh in Genome Data Viewer
    Location:
    3p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (30886313..30903313)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (10488260..10505245)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (5709236..5731895)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 163, member B Neighboring gene uncharacterized LOC134486349 Neighboring gene uncharacterized LOC102548789 Neighboring gene sarcosine dehydrogenase Neighboring gene vav guanine nucleotide exchange factor 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-ascorbic acid binding  
    enables copper ion binding  
    enables copper ion binding  
    enables copper ion binding PubMed 
    enables copper ion binding  
    enables copper ion binding  
    enables dopamine beta-monooxygenase activity  
    enables dopamine beta-monooxygenase activity PubMed 
    enables dopamine beta-monooxygenase activity  
    enables dopamine beta-monooxygenase activity PubMed 
    enables dopamine beta-monooxygenase activity  
    enables dopamine beta-monooxygenase activity PubMed 
    Items 1 - 25 of 69
    Process Evidence Code Pubs
    acts_upstream_of_or_within associative learning  
    involved_in behavioral response to ethanol  
    acts_upstream_of_or_within behavioral response to ethanol  
    involved_in blood vessel remodeling  
    acts_upstream_of_or_within blood vessel remodeling  
    involved_in bone development PubMed 
    involved_in catecholamine metabolic process PubMed 
    involved_in cellular response to manganese ion PubMed 
    involved_in cellular response to nicotine PubMed 
    involved_in dopamine catabolic process  
    involved_in dopamine catabolic process  
    acts_upstream_of_or_within dopamine catabolic process  
    involved_in dopamine catabolic process  
    involved_in dopamine catabolic process  
    involved_in fear response  
    acts_upstream_of_or_within fear response  
    involved_in glucose homeostasis  
    acts_upstream_of_or_within glucose homeostasis  
    involved_in homoiothermy  
    acts_upstream_of_or_within homoiothermy  
    involved_in leukocyte mediated immunity  
    acts_upstream_of_or_within leukocyte mediated immunity  
    involved_in leukocyte migration  
    acts_upstream_of_or_within leukocyte migration  
    involved_in locomotory behavior  
    acts_upstream_of_or_within locomotory behavior  
    involved_in locomotory behavior  
    involved_in maternal behavior  
    acts_upstream_of_or_within maternal behavior  
    involved_in memory  
    acts_upstream_of_or_within memory  
    involved_in norepinephrine biosynthetic process  
    involved_in norepinephrine biosynthetic process  
    involved_in norepinephrine biosynthetic process PubMed 
    acts_upstream_of_or_within norepinephrine biosynthetic process  
    involved_in norepinephrine biosynthetic process  
    involved_in norepinephrine biosynthetic process  
    involved_in norepinephrine biosynthetic process PubMed 
    involved_in octopamine biosynthetic process  
    involved_in octopamine metabolic process PubMed 
    involved_in positive regulation of cold-induced thermogenesis  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of vasoconstriction  
    acts_upstream_of_or_within positive regulation of vasoconstriction  
    involved_in regulation of extrinsic apoptotic signaling pathway  
    acts_upstream_of_or_within regulation of extrinsic apoptotic signaling pathway  
    involved_in regulation of vascular associated smooth muscle cell proliferation  
    acts_upstream_of_or_within regulation of vascular associated smooth muscle cell proliferation  
    involved_in regulation of vascular endothelial cell proliferation  
    acts_upstream_of_or_within regulation of vascular endothelial cell proliferation  
    involved_in response to amphetamine  
    acts_upstream_of_or_within response to amphetamine  
    involved_in response to copper ion PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to immobilization stress PubMed 
    involved_in response to iron ion PubMed 
    involved_in response to isolation stress PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to ozone PubMed 
    involved_in response to pain  
    acts_upstream_of_or_within response to pain  
    involved_in response to peptide hormone PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in social behavior PubMed 
    involved_in vasoconstriction  
    acts_upstream_of vasoconstriction  
    involved_in visual learning  
    acts_upstream_of_or_within visual learning  
    Items 1 - 25 of 69
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    located_in apical part of cell PubMed 
    located_in axon PubMed 
    located_in centriolar satellite  
    located_in centriolar satellite  
    located_in chromaffin granule lumen  
    located_in chromaffin granule membrane  
    located_in dendrite PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    located_in intracellular membrane-bounded organelle  
    located_in neuronal cell body PubMed 
    located_in secretory granule lumen  
    located_in secretory granule lumen  
    is_active_in secretory granule membrane  
    located_in secretory granule membrane  
    located_in secretory granule membrane  
    located_in terminal bouton PubMed 
    located_in transport vesicle membrane  
    located_in varicosity PubMed 
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    dopamine beta-hydroxylase
    Names
    Dopamine beta hydroxylase (dopamine beta-monooxygenase)
    dopamine beta-monooxygenase
    NP_037290.3
    XP_063139234.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013158.3NP_037290.3  dopamine beta-hydroxylase precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q05754
      UniProtKB/TrEMBL
      A6JTK7, G3V9S4
      Related
      ENSRNOP00000057915.1, ENSRNOT00000061201.5
      Conserved Domains (3) summary
      pfam01082
      Location:217340
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03351
      Location:60175
      DOMON; DOMON domain
      pfam03712
      Location:363519
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      30886313..30903313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283164.1XP_063139234.1  dopamine beta-hydroxylase isoform X1

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