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    Rab6a RAB6A, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84379, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab6aprovided by RGD
    Official Full Name
    RAB6A, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:619737
    See related
    EnsemblRapid:ENSRNOG00000018176 AllianceGenome:RGD:619737
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rab6; Rab6b; RCO4-3
    Summary
    Enables ATPase activator activity; ATPase binding activity; and GTP binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; intracellular protein transport; and protein localization to Golgi membrane. Predicted to act upstream of or within peptidyl-cysteine methylation. Is active in presynapse. Orthologous to human RAB6A (RAB6A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 1044.9), Muscle (RPKM 339.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rab6a in Genome Data Viewer
    Location:
    1q32
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164370033..164422324)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154957870..155008922)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165624973..165664201)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099894 Neighboring gene cytochrome c oxidase assembly factor 4 homolog Neighboring gene mitochondrial ribosomal protein L48 Neighboring gene small nucleolar RNA SNORA4 Neighboring gene pleckstrin homology domain containing B1 Neighboring gene family with sequence similarity 168, member A Neighboring gene RELT, TNF receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase activator activity PubMed 
    enables ATPase binding PubMed 
    enables GTP binding PubMed 
    enables GTP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables myosin V binding  
    enables myosin V binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein domain specific binding  
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction PubMed 
    involved_in antigen processing and presentation  
    involved_in antigen processing and presentation  
    involved_in early endosome to Golgi transport  
    involved_in early endosome to Golgi transport  
    involved_in intra-Golgi vesicle-mediated transport  
    involved_in intracellular protein transport  
    acts_upstream_of_or_within peptidyl-cysteine methylation  
    involved_in protein localization to Golgi apparatus  
    involved_in protein localization to Golgi apparatus  
    involved_in protein localization to Golgi membrane  
    involved_in protein localization to Golgi membrane  
    involved_in protein localization to Golgi membrane  
    involved_in protein localization to Golgi membrane  
    involved_in retrograde transport, endosome to Golgi  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in Golgi membrane  
    located_in Golgi membrane  
    located_in acrosomal membrane  
    located_in acrosomal membrane  
    located_in acrosomal membrane  
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in cytosol  
    is_active_in endomembrane system  
    located_in endosome to plasma membrane transport vesicle  
    located_in endosome to plasma membrane transport vesicle  
    located_in membrane  
    located_in membrane  
    is_active_in presynapse PubMed 
    is_active_in presynapse PubMed 
    located_in trans-Golgi network  
    located_in trans-Golgi network  
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    ras-related protein Rab-6A
    Names
    RAB6, member RAS oncogene family
    RAB6B, member RAS oncogene family
    rab-6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414455.1NP_001401384.1  ras-related protein Rab-6A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 and 2 include either one of two duplicated, alternatively spliced coding exons and are the same length. The resulting proteins (isoforms 1 and 2, respectively) are the same length but differ at three amino acid positions. This variant (1) encodes isoform 1.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q9WVB1
      UniProtKB/TrEMBL
      A0A0H2UHP9, A6I6Q3
      Related
      ENSRNOP00000025104.6, ENSRNOT00000025104.8
    2. NM_053366.2NP_445818.1  ras-related protein Rab-6A isoform 2

      See identical proteins and their annotated locations for NP_445818.1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 and 2 include either one of two duplicated, alternatively spliced coding exons and are the same length. The resulting proteins (isoforms 1 and 2, respectively) are the same length but differ at three amino acid positions. This variant (2) encodes isoform 2.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZJD7, A6I6Q2
      Related
      ENSRNOP00000091495.2, ENSRNOT00000106849.2
      Conserved Domains (1) summary
      cd01861
      Location:14174
      Rab6; Rab GTPase family 6 (Rab6)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      164370033..164422324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092745.2XP_038948673.1  ras-related protein Rab-6A isoform X1

      Related
      ENSRNOP00000104096.1, ENSRNOT00000164517.1
      Conserved Domains (1) summary
      cd01861
      Location:14173
      Rab6; Rab GTPase family 6 (Rab6)

    RNA

    1. XR_010058322.1 RNA Sequence

    2. XR_005493259.2 RNA Sequence

    3. XR_010058323.1 RNA Sequence

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