Dip2a disco-interacting protein 2 homolog A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dip2aprovided by RGD
Official Full Name: disco-interacting protein 2 homolog Aprovided by RGD
Primary source: RGD:1582897
See related: EnsemblRapid:ENSRNOG00000043212 AllianceGenome:RGD:1582897
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable acetate-CoA ligase activity. Predicted to be involved in several processes, including dendritic spine morphogenesis; positive regulation of peptidyl-lysine acetylation; and regulation of modification of postsynaptic actin cytoskeleton. Predicted to be located in dendritic spine; membrane; and mitochondrion. Predicted to be active in cell surface; glutamatergic synapse; and postsynapse. Orthologous to human DIP2A (disco interacting protein 2 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 101.0), Lung (RPKM 77.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (12284037..12373519)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (12284566..12371068)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (13044056..13127971)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

ha3097 (e-PCR)
- UniSTS:515645

BF387311 (e-PCR)
- UniSTS:244313

Dip2a (e-PCR), detects polymorphism
- UniSTS:546739

RH140110 (e-PCR)
- UniSTS:222190

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetate-CoA ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disco-interacting protein 2 homolog A

Names: DIP2 disco-interacting protein 2 homolog A

NP_001178493.2

EC 6.2.1.1

XP_038955005.1

EC 6.2.1.1

XP_063135591.1

EC 6.2.1.1

XP_063135592.1

EC 6.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191564.3 → NP_001178493.2 disco-interacting protein 2 homolog A

Status: INFERRED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A0G2KB74

Related

ENSRNOP00000111726.1, ENSRNOT00000140381.1

Conserved Domains (2) summary

cd05905
Location:993 → 1557

Dip2; Disco-interacting protein 2 (Dip2)

pfam06464
Location:10 → 121

DMAP_binding; DMAP1-binding Domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

12284037..12373519

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099077.2 → XP_038955005.1 disco-interacting protein 2 homolog A isoform X1

UniProtKB/TrEMBL

A0A0G2KB74, F1LZ43

Related

ENSRNOP00000060375.4, ENSRNOT00000066017.5

Conserved Domains (2) summary

cd05905
Location:993 → 1567

Dip2; Disco-interacting protein 2 (Dip2)

pfam06464
Location:10 → 121

DMAP_binding; DMAP1-binding Domain
XM_063279522.1 → XP_063135592.1 disco-interacting protein 2 homolog A isoform X3

UniProtKB/TrEMBL

A0A0G2KB74

Related

ENSRNOP00000102530.1, ENSRNOT00000167478.1
XM_063279521.1 → XP_063135591.1 disco-interacting protein 2 homolog A isoform X2

UniProtKB/TrEMBL

A0A0G2KB74