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    H4cl1 histone H4C like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 102548682, updated on 9-Dec-2024

    Summary

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    Official Symbol
    H4cl1provided by RGD
    Official Full Name
    histone H4C like 1provided by RGD
    Primary source
    RGD:7725170
    See related
    AllianceGenome:RGD:7725170
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of chromatin. Predicted to be involved in negative regulation of megakaryocyte differentiation and nucleosome assembly. Predicted to be located in nucleus. Predicted to be part of CENP-A containing nucleosome. Orthologous to several human genes including H3C13 (H3 clustered histone 13); H3C14 (H3 clustered histone 14); and H3C15 (H3 clustered histone 15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See H4cl1 in Genome Data Viewer
    Location:
    17p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (41796600..41860389)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (41368743..41426735)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (43616218..43673659)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 17, member 2 Neighboring gene H1.1 linker histone, cluster member Neighboring gene tripartite motif containing 38 Neighboring gene uncharacterized LOC134482711 Neighboring gene uncharacterized LOC134482710 Neighboring gene H3 clustered histone 1 Neighboring gene histone cluster 1 H2A family member F Neighboring gene histone cluster 1 H2A family member H Neighboring gene H2B clustered histone 3 Neighboring gene PC-esterase domain containing 1A, pseudogene 1 Neighboring gene H1.2 linker histone, cluster member Neighboring gene homeostatic iron regulator Neighboring gene Histone cluster 1, H2an-like 1, pseudogene 2 Neighboring gene histone cluster 1 H2B family member Q Neighboring gene H1.6 linker histone, cluster member Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase. Mitra P, et al. Mol Cell Biol, 2003 Nov. PMID 14585971, Free PMC Article
    2. PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation. Sims JK, et al. Mol Cell Biol, 2008 Jul. PMID 18474616, Free PMC Article
    3. Structure of human nucleosome containing the testis-specific histone variant TSH2B. Urahama T, et al. Acta Crystallogr F Struct Biol Commun, 2014 Apr. PMID 24699735, Free PMC Article
    4. Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis. Zhai N, et al. J Mol Cell Biol, 2012 Aug. PMID 22368283
    5. Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T. Tachiwana H, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20498094, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CENP-A containing nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein H4cl1
    Names
    histone H3
    histone H4
    histone H4-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      41796600..41860389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600719.3 → XP_017456208.2  uncharacterized protein H4cl1

      Conserved Domains (2) summary
      PLN00035
      Location:240 → 342
      PLN00035; histone H4; Provisional
      PTZ00018
      Location:125 → 237
      PTZ00018; histone H3; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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